CART: A NOVEL COCAINE REGULATED NEUROCHEMICAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的一年里取得了非常实质性的进展。主要的发现是通过信号和结合在AtT20细胞中鉴定出CART受体。这一进展将允许在受体上筛选潜在的药物，并为克隆受体提供工具。此外，我们提供了CART基因敲除小鼠具有多种行为变化的证据，这支持了许多文献表明CART在许多生理过程中发挥着重要作用。我们还发现CART对疼痛和压力有作用，从药物开发的角度来看，这也是值得的。在一项数学建模研究中，我们发现药物依赖的发生符合蛋白质合成的模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Very substantial progress has been made over the past year. The major finding has been the identification of a CART receptor in AtT20 cells by signaling and binding. This advance will allow screening of potential medications at the receptor and provide tools for cloning the receptor. In addition, we provided evidence that CART knockout mice have a variety of behavioral changes which supports many papers indicating an important role for CART in many physiological processes. We also found that CART has a role in pain and stress which are also worthwhile from the point of view of drug development. In a math modeling study, we showed that the onset of drug dependence fits a model of protein synthesis.