EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的长期目标是揭示解释婴儿斜视(眼睛错位)每种行为缺陷的神经机制，以及它们发生的发育时间。该项目的具体目标是确定关键期早期的眼睛重排是否可以修复由婴儿斜视引起的视觉皮质的行为和结构缺陷。新生的猕猴是戴着布拉德利博士为幼猴设计的护目镜饲养的，这种护目镜配备了棱镜来诱导光学斜视。斜视在出生后3周、3个月、6个月的三种年龄中的一种被“修复”；对应于儿童的“极早”(人类：3个月大)、“平均”(人类：12个月大)和“晚”(人类：2岁)斜视手术。在这种准备过程中，斜视的修复包括摘除棱镜护目镜的简单动作。今年，我们改变了发病年龄，无论是出生、3周还是6周，以确定所获得的结果是由于棱镜饲养时间还是矫正年龄所致。为这个项目产生的具体假设都有一个共同的预测，即眼睛越早调整，视觉功能的恢复就越大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. Newborn macaques are reared wearing Dr. Bradley's goggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. The strabismus is "repaired" at one of three postnatal ages: 3 weeks, 3 months, 6 months; corresponding to "very early" (humans: 3 months of age), "average" (humans: 12 months of age), and "late" (humans: 2 years of age) strabismus surgery in children. In this preparation, repair of strabismus consists of the simple act of the removal of the prism goggles. This year we varied the age of onset, either birth, 3 weeks, or 6 weeks, in order to determine whether the results obtained were due to duration of prism rearing or age at correction. The specific hypotheses generated for this project have in common the prediction that the earlier the realignment of the eyes, the greater the recovery of visual function.