Resource Core

科学资源核心（SRC）作为一个独立的核心已经出现了11-15年的MARC， 认可4个拟议研究项目和试点研究中反映的跨领域活动，以及 在R 01系列相关研究中。SRC的首要目标是提供重要的基础设施 通过三个广泛领域， 目的：（1）一般人口数据库管理和操作，以支持主题确定， 随访和通过密苏里州家庭登记（“MFR”）的新研究设计;（2）表型，环境 和基因型信息管理系统（“PEGIMS”），其包括跨以下研究的协调： 诊断表型和环境风险暴露，为这些建立中央数据库，以及 中心项目中收集的基因型数据的中央数据库;以及（3）继续评估 协调和协商（“ACC”），以确保在人类活动范围内的测量的兼容性。 研究（实验室、实验、调查）和方式（掌上试点、网络、访谈、问卷） 促进交叉研究分析，这是一个在全基因组时代特别引人注目的研究领域。 相关性研究和随之而来的大样本要求。核心资源对于实现 当前基于中心和与中心相关的项目，包括重要的研究支持功能， 这是不可能由个别研究人员自己获得的。核心利用了 中心的跨学科科学小组负责协调和统一职能。核心还服务于 一个重要的培训和教师发展的目的，提供资源，重要的初级 研究人员寻求在酒精研究中建立独立的职业生涯。管理的资源和 在SRC中保持独特的地位，该中心继续其工作，揭示风险 酒精中毒和共病表型的发展过程，通过促进：信息采样 来自一般人群;在不同人群中基因-环境相互作用随时间的交叉研究分析 对样本进行协调诊断和环境风险暴露; 跨研究协调评估，以供未来调查和跨研究分析。

The Science Resource Core (SRC) has emerged as an independent core for years 11-15 of the MARC, in recognition of the cross-cutting activities reflected in the 4 proposed Research Projects and pilot studies, and in the series of related R01 studies. The overarching goal of the SRC is to provide important infrastructure support and assessment coordination for Center-based and Center-affiliated research, through three broad aims: (1) general population database management and manipulation in support of subject ascertainment, follow-up, and novel study design thru the Missouri Family Register ("MFR"); (2) phenotype, environmental and genotype information management systems ("PEGIMS") which include harmonization across studies of diagnostic phenotypes and environmental risk exposures, creation of centralized databases for these, and a central database of the genotypic data collected in the Center projects; and (3) continuation of assessment coordination and consultation ("ACC") to ensure compatibility of measurements across the range of human research (laboratory, experimental, survey) and modalities (palm pilot, web-based, interview, questionnaire) to facilitate cross-study analysis, a line of research that is particularly compelling in the era of Genome-wide association studies and the concomitant requirement of huge samples. Core resources are essential to the current Center-based and Center-related projects, encompassing important research support features hat would not be feasible for individual investigators to obtain on their own. The Core takes advantage of the Center's interdisciplinary scientific group for coordination and harmonization functions. The core also serves an important training and faculty development purpose by providing resources important to junior investigators as they seek to establish independent careers in alcohol research. Resources managed and maintained in the SRC uniquely position the Center to continue its work of shedding light on the risk processes in the development of alcoholism and comorbid phenotypes by facilitating: informative sampling from the general population; cross study analyses of gene-environment interplay over time in different samples with coordinated diagnoses and environmental risk exposures; and continued maintenance of coordinated assessments across studies for future investigation and cross-study analyses.