COMMON LIFE STRESSES & FERTILITY IN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目调查了日常生活压力在导致女性和非人类灵长类动物不孕不育方面所起的作用。它建立在我们之前的发现基础上，即一些人对压力非常敏感，很容易表现出压力诱导的生殖功能抑制，而另一些人则具有压力弹性，在压力下保持正常的月经周期。我们发现，与更具应激弹性的个体相比，应激敏感个体的中枢5-羟色胺能神经元活性较低，这在生理上和基因表达的变化上都表明了这一点。在这项资助中，具体目标1是确定选择性5-羟色胺再摄取抑制剂(SSRI)的治疗是否会增加应激敏感个体的应激恢复能力。具体目标2是确定应激敏感和应激恢复个体中枢神经系统基因表达和活性的差异。具体目标3研究压力对压力敏感和有压力恢复能力的个体的卵泡和卵母细胞成熟的影响。特定目的4检测压力敏感型和应激恢复型动物下丘脑-垂体-肾上腺(HPA)轴的活性。特定目的4检测应激敏感型和应激恢复型动物下丘脑-垂体-肾上腺轴的活性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress-resilience of stress sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines the effects of stress on follicular and oocyte maturation in stress-sensitive and stress-resilient individuals. Specific Aim 4 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitivie vs. stress-resilient animals. Specific Aim 4 examines activity of the hypothalamic-pituitary-adrenal axis in stress-sensitive vs. stress-resilient animals.