GENETICS OF ANXIOUS/DEPRESSIVE BEHAVIOR IN MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项与匹兹堡大学和西南基金会合作的研究中，我们正在研究恒河猴行为的遗传基础，这些行为与人类焦虑症相关的行为和气质特征相似。本研究使用一组8项焦虑行为测试来识别恒河猴婴儿的气质特征，这些测试是从幼儿的临床测试中改编而来的。 与焦虑和抑郁相关的生理属性，特别是对药物刺激的生长激素反应迟钝，下丘脑-垂体-肾上腺轴的活性，以及脑脊液神经递质水平也正在被测量。 每项猴子研究都使用350个微卫星标记进行全基因组扫描，然后进行连锁分析，以确定与焦虑行为特定方面相关的染色体区域。 在ONPRC，正在对猴子进行行为表型分析和生理测量。 西南基金会正在分析所有的DNA，匹兹堡大学正在进行连锁分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, a collaboration with the University of Pittsburgh and the Southwest Foundation, we are examining the genetic underpinnings of behaviors in rhesus monkeys that parallel behavioral and temperamental traits linked to anxiety disorders in humans. This study is identifying temperamental characteristics in infant rhesus monkeys using a set of 8 tests of anxious behavior which have been adapted from clinical tests used with young children. Physiological attributes associated with anxiety and depression, specifically blunted growth hormone responsiveness to pharmacological stimulation, activity of the hypothalamic-pituitary-adrenal axis, and cerebral spinal fluid neurotransmitter levels are also being measured. Each monkey study has a genome-wide scan using 350 microsatellite markers and then linkage analyses are run to identify chromosomal regions associated with specific aspects of anxious behavior. At ONPRC the monkeys are being behaviorally phenotyped and physiological measures are made. At the Southwest Foundation all of the DNA is being analyzed, and linkage analyses are being performed at the University of Pittsburgh.