MULTICENTER ANALYSIS OF HIPPOCAMPAL MORPHOLOGY IN MCI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项建议将为30名轻度认知障碍(MCI)患者(其中15名根据纵向随访已知患有早期AD)和30名老年对照组的海马萎缩的影像评估提供中心间的可靠性、敏感性和特异性。四种成像技术将在来自全国多个中心的通用数据集上进行评估。这四种技术的选择是基于它们在评估内侧颞叶萎缩方面的有效性。这些方法包括：1.Mayo组的容量评估技术。2.NYU组对内侧颞叶萎缩的定性评估。3.Jobst等人的线性评价技术。4.加州大学洛杉矶分校采用的三维测绘技术。参与这项多站点协议的中心共享MCI和常见MRI采集序列的共同定义：1.加州大学洛杉矶分校ADRC和神经成像实验室2.梅奥诊所ADRC和放射科3.纽约大学ADRC和放射科的具体目标：(1)使用在对照和MCI患者身上获得的公共共享扫描数据库，获得关于这四种技术的中心间可靠性数据。(2)获得这四种评估技术在识别MCI与对照受试者中跨中心的敏感性和特异性数据；[和MCI队列中的15名早期AD受试者](3)使用这项研究得出的中心范围的规范对照数据及其关于海马体体积变异性的数据，提供基于网络的工具来评估未来的MCI患者，使用特定目标#2中确定的最有效和临床有用的技术。这个基于网络的工具将通过互联网提供给任何诊所或中心，并且将是独立于平台的，允许基于从本提案获得的共享的成像和临床数据资源来评估任何特定受试者早期AD的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal will provide intercenter reliability, sensitivity, and specificity on imaging assessment of hippocampal atrophy in 30 patients with mild cognitive impairment (MCI) [15 of which are known to have incipient AD based upon longitudinal follow-up] compared to 30 elderly controls. Four imaging techniques will be assessed on a common data set derived from multiple centers across the country. These four techniques have been chosen based upon their demonstrated usefulness in evaluating medial temporal atrophy. These include: 1. The volumetric assessment technique of the Mayo group. 2. The qualitative assessment of medial temporal lobe atrophy performed by the NYU group. 3. The linear assessment technique of Jobst et al. 4. The three-dimensional mapping technique employed at UCLA. The centers participating in this multisite protocol who share common definitions of MCI and common MRI acquisition sequences are: 1. The UCLA ADRC and Laboratory of Neuro Imaging 2. The Mayo Clinic ADRC and Department of Radiology 3. The NYU ADRC and Department of Radiology Specific aims: (1) Obtain inter-center reliability data on these four techniques using a common shared database of scans obtained on both control and MCI patients. (2) Obtain sensitivity and specificity data on these four assessment techniques across centers in the identification of MCI vs. control subjects; [and the 15 incipient AD subjects within the MCI cohort] (3) Using the center-wide normative control data derived from this study, with its data on hippocampal volumetric variability, provide web-based tools to assess future patients with MCI using the most efficient and clinically useful technique identified in specific aim #2. This web-based tool will be made available to any clinic or center via the Internet and will be platform independent to allow assessment of any given subject's risk for incipient AD based up on the shared resources of imaging and clinical data derived from this present proposal.