SPATIAL SPECIFICITY OF HIGH-RESOLUTION, SPIN-ECHO BOLD AND CBF FMRI AT 7T

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在信中，杜恩博士表达了对 我们的自旋回波(SE)粗体和基于CBF的空间特异性 由于固有的功能映射信号(1) EPI图像中的T*2加权，对SE的血液贡献 基于CBF的功能磁共振成像中的粗体和粗体效果。详细 对这些观点的验证或讨论超出了 我们第(1)条的范围，因为它是作为说明提交的 (虽然以通信形式发布)地址 高分辨率SE BOLD和CBF功能磁共振成像的技术问题 在4T和7T的人类中，EPI面临着主要的困难- 邪教。因此，我们对空间特殊性的评论 是基于高场动物研究的 (2，3)。然而，杜恩博士提出的问题确实是 在原来的文章(1)中提到的，并得到了充分的处理 随后不久发表了两篇文章(4，5)。我们的 对杜恩？S博士的回应概括如下三点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In his letter, Dr. Duyn expresses concerns regarding the spatial specificity of our spin-echo (SE) BOLD and CBFbased functional mapping signals (1) because of inherent T*2 weighting in EPI images, blood contributions to SE BOLD, and BOLD effects in CBF-based fMRI. Detailed verification or discussion of these points was beyond the scope of our article (1), since it was submitted as a Note (although published as a Communication) addressing technical issues of high-resolution SE BOLD and CBF fMRI in humans at 4 and 7 T where EPI confronts major diffi- culties. Consequently, our remarks on the spatial specificity of fMRI were based on animal studies at high fields (2,3). However, the issues voiced by Dr. Duyn were indeed mentioned in the original article (1), and were fully dealt with in two articles published shortly afterwards (4,5). Our responses to Dr. Duyn?s three points are summarized below.