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PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM

PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM
血吸虫宿主入侵和代谢的蛋白质组学分析
批准号：
7724192
负责人：
James H. McKerrow
金额：
$0.87万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-06-01 至 2009-05-31
来源：
https://reporter.nih.gov/project-details/7724192
关键词：
Computer Retrieval of Information on Scientific Projects DatabaseEndopeptidasesFundingGrantHumanIncubatedInstitutionInvasiveLarvaMetabolismPeptide HydrolasesProteomicsResearchResearch PersonnelResourcesSchistosomaSkinSourceUnited States National Institutes of Healthresearch study

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这些实验中，我们试图确定侵袭性血吸虫幼虫在皮肤中的蛋白酶的天然底物。血吸虫尾蚴与人体皮肤切片和提取的降解产物一起孵化。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In these experiments, we are attempting to identify the natural substrates for the protease of invasive schistosome larvae in skin. Schistosome cercariae are incubated with sections of human skin and products of degradation extracted.
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Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
HYDROLYSIS OF HEMOGLOBIN BY SCHISTSOMA MANSONI CATHEPSIN B-LIKE CYSTEINEPROTEASE
STRUCTURE BASED DRUG DESIGN FOR TREATMENT OF PARASITIC AND VIRAL DISEASES
GIARDIA LAMBLIA CYSTEINE PROTEASES: TRAFFICKING, LOCALIZATION, AND FUNCTION
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