DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 漫反射光学作为一种床边监测器有着很大的前景，可以作为血液流动、组织的监测器 大脑中的血氧饱和度和氧代谢。近红外光谱分析 (近红外光谱)和成像技术已经开发了一段时间，并取得了重大进展 已经做好了。我们实验室在这一子领域中发挥了领先作用。最近， 我们介绍了一种名为漫相关光谱(DCS)的新技术 允许我们测量组织血流量以及血氧饱和度和总血红蛋白 集中精神。通过将这些方法结合在一种混合技术中，我们现在可以 对潜在的大脑生理学有更好的了解，我们甚至可以估计大脑的氧气 新陈代谢作为大脑健康的替代标记物。漫反射光学的主要特征 方法是它作为床边连续、非侵入性、定量监测的潜力。我们 预计它将在未来应用于其他大脑疾病，但因为清楚 中风的理论基础和巨大的公共卫生意义，我们最近选择关注 在急性皮质卒中的管理方面的努力。通过开发中风监测器，我们希望 往往以优化脑血流为重点的医疗管理可以 根据每个患者的基本病理生理进行优化和个性化。我们有 现在证明了它们在完整的人脑和患者的功能激活研究中的应用 患有急性中风。进一步的理论、算法和技术发展是必要的 以提高这些数据的保真度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great of promise as a bed-side monitor as a monitor of blood flow, tissue blood oxygen saturation and oxygen metabolism in the brain. Near-Infrared spectroscopy (NIRS) and imaging has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) which permits us to measure tissue blood flow as well as blood oxygen saturation and total hemoglobin concentration. By combining these methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and we can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, noninvasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing a stroke monitor, we hope that the medical management which often focuses on optimization of cerebral blood flow can be optimized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic and technological developments are necessary to improve the fidelity of these data.