TOXICOLOGY MODULE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 毒理学已被确定为专题领域，BioCurrents集团开发的工具和专业知识可以找到强大的应用。 为了进一步实现这一目标，由UMDNJ和罗格斯大学的杰弗里·拉斯金（Jeffrey Laskin）协调，形成了一个研究模块。 他特别感兴趣的领域是环境毒物，因为它们影响新陈代谢和免疫反应。 拉斯金是MBL的长期访问者，并与BRC合作首次将一氧化氮传感器应用于单细胞研究。 2005年是该单元活动的第一年，仅在夏季几个月集中开展活动。 一群来自伍兹霍尔和新泽西的活跃调查人员在6月至9月期间共同合作。 该小组在布拉迪斯拉发区域中心组织了一次“毒理学圆桌会议”，在7月和8月期间每周举行一次会议，讨论环境毒理学问题和布拉迪斯拉发区域中心技术在毒理学中的应用。 主题的例子包括Hans Laufer关于内分泌干扰物在改变上皮细胞氧化应激中的作用的讨论，

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Toxicology has been identified as thematic area where the tools and expertise developed by the BioCurrents group could find powerful applications. To further that goal a research module was formed, coordinated by Jeffrey Laskin of UMDNJ and Rutgers University. His particular area of interest is in environmental toxicants as they impact metabolism and immune responses. Laskin has been a long time visitor to the MBL and worked with BRC on the first application of a nitric oxide sensor to single cell studies. 2005 was the first year of this module's activity, which was focused only in the summer months. A group of active investigators from Woods Hole and New Jersey collaborated together between June and September. The group organized a 'Toxicology Roundtable" at the BRC which met weekly during the months of July and August to discuss issues in environmental toxicology and applications of BRC technology in toxicology. Examples of topics included discussion by Hans Laufer on the role of endocrine disruptors in modifying oxidative stress in epithelial cells and