Emotion, communication, & EEG: Development & risk

描述(由申请者提供)：该项目将使用早期情绪功能和交流的发展模式来预测第二和第三年的社会、行为和认知功能。对比100名典型发育中的婴儿兄弟姐妹和100名患有自闭症谱系障碍(ASD)儿童的婴儿兄弟姐妹--他们面临一系列情绪、沟通和认知障碍的风险--将从发育精神病理学的角度阐明这些发育过程。在生命的第一年，将确定积极和消极情绪的气质(Lab-TAB)和交际性(面对面/静止)评估、接近动机的大脑指数(EEG偏侧性)和交流意向(婴儿联合注意)的发展之间的联系。这些结构将被用来预测一系列与发展相关的过程，包括二元关系质量、父母评估的行为困难和优势、语言和认知功能的标准化测量，以及第二和第三年的自闭症相关症状。关系质量是一个核心结构，包括依恋的安全感、父母的温暖和控制，以及儿童在一系列社会情景中的合作和战争。除ASD症状外，人际关系质量被认为是所有结果的中介途径。患有高水平自闭症症状的儿童预计会在早期的情感交流和后来的社交、交流和认知功能方面表现出缺陷。ASD的症状被认为与早期的情绪功能直接相关。这一建议利用多种方法评估婴儿早期的情绪功能，以应对预测意向交流和后来的健康互动指数以及胜任的语言和认知功能的任务。测试的模型将为预测和预防与健康相关的结果提供具体的线索，包括行为问题、不良关系质量和自闭症症状在处于风险和典型发展中的样本中。对典型发育中的婴儿和患有自闭症儿童的婴儿兄弟姐妹的预测相关性的检查将有助于揭示健康发展的途径、与这些途径的精神病理偏差，以及对有发育困难风险的婴儿的潜在干预策略。

DESCRIPTION (provided by applicant): This project will use developmental patterns of early emotional functioning and communication to predict social, behavioral, and cognitive functioning in the second and third year of life. Contrasts between 100 typically developing infant siblings and 100 infant siblings of children with Autism Spectrum Disorder (ASD) - who are at risk for a range of disruptions of emotion, communication, and cognition - will illuminate these developmental processes from a developmental psychopathology perspective. In the first year of life, associations between temperamental (Lab-TAB) and communicative (face-to-face/still-face) assessments of positive and negative emotion, cerebral indices of approach motivation (EEG laterality), and the development of communicative intentionality (infant joint attention) will be determined. These constructs will be used to predict a set of developmental^ linked processes including dyadic relationship quality, parent rated behavioral difficulties and strengths, standardized measures of linguistic and cognitive functioning, and ASD- related symptomatology in the second and third year of life. Relationship quality is a central construct, encompassing security of attachment, parental warmth and control, and child cooperation and warmeth in a range of social situations. Relationship quality is expected to mediate pathways to all outcomes with the exception of ASD symptomatology. Children with high levels of ASD symptomatology are expected to show deficits in both early measures emotional communication and later measures of social, communicative, and cognitive functioning. ASD symptomatology is expected to be directly related to early emotional functioning. This proposal utilizes multi-method assessment of emotional functioning early in infancy to confront the task of predicting intentional communication and later indices of healthy interaction, and competent linguistic and cognitive functioning. The models tested will shed specific light on the prediction and prevention of health- related outcomes including behavior problems, poor relationship quality, and ASD symptomatology in an at- risk and typically developing sample. Examination of predictive associations in typically developing infants and infant siblings of children with ASD will shed light on pathways to healthy development, psychopathologic deviations from those pathways, and potential intervention strategies for infants at risk for developmental difficulties.