California NeuroAIDS Tissue Network (CNTN)

描述（由申请人提供）：本申请更新加州神经aids组织网络（CNTN）响应RFA-MH-08-021。CNTN是国家神经艾滋病组织联盟（NNTC）的一部分，该联盟包括西奈山医学院、加州大学洛杉矶分校和德克萨斯大学加尔维斯顿分校。与RFA的要求一致，本申请分为两部分：A部分（与所有4个申请相同）描述了NNTC的总体目标和运作，包括通用协议和共享科学议程。B部分是站点特定的应用程序，如下所述。CNTN的主要目标是对艾滋病毒感染者进行仔细的神经医学、神经精神和实验室评估，以便将这些数据与从研究中死亡并同意器官捐赠的参与者的大脑和其他组织中获得的神经病理学信息联系起来。这使我们能够通过向调查人员提供组织、液体和数据来支持全国各地的研究，使他们能够回答有关艾滋病神经系统疾病的原因和可能的治疗和预防的关键问题。到目前为止，CNTN拥有544名艾滋病毒感染者的生前临床信息，并分析了198名艾滋病毒感染者的大脑和其他组织。我们还将20名未感染艾滋病毒的人的组织储存起来

DESCRIPTION (provided by applicant): This application for renewal of the California NeuroAIDS Tissue Network (CNTN) responds to RFA-MH-08-021. The CNTN is part of the National NeuroAIDS Tissue Consortium (NNTC) which includes sites at the Mt. Sinai School of Medicine, UCLA, and University of Texas Galveston. Consistent with the RFA's requirements, this application is in two parts: Part A (identical for all 4 applications) describes the overall aims and operations of the NNTC, including common protocols and shared scientific agendas. Part B is the Site specific application, which is described below. The CNTN's main objective has been to perform careful neuromedical, neuropsychiatric, and laboratory evaluations of persons with HIV so that these data can be linked to neuropathological information obtained from brain and other tissues of participants who die on study and consent to organ donation. This enables us to support research throughout the country by providing investigators with tissues, fluids, and data that will keep them to answer critical questions on the causes and possible treatment and prevention of neurologic disease in AIDS. To date CNTN has antemortem clinical information on 544 persons living with HIV and have analyzed brain and other tissues from 198 HIV+ persons. We have also banked tissues from 20 HIV uninfected persons for comparison study. As an active member of the NNTC, CNTN contributes data to the NNTC Coordinating Office, which has enabled NNTC to respond to 212 requests from various investigators. In this continuation phase CNTN plans to augment its resource mission with a scientific agenda, as envisioned in the RFA. Initial scientific analyses will focus on neuropathologic characteristics of immune reconstitution inflammatory syndrome, an exploration of the cellular basis and structural correlates of HIV leukoencephalopathy, mechanisms of early neuronal aging among persons with prolonged exposure to HIV and ARV treatment, and the role of viral drug resistance in HIV brain disease. Our resource contributions to the NNTC will include membership in the NNTC's Scientific Leadership Group, collaboration on NNTC-wide preliminary studies and QA activities, technical assistance in areas of CNTN's expertise, and continuing contribution of data from antemortem and postmortem evaluations. Part A: