Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts.
Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts.
批准号:
nhmrc : 516740
负责人:
A/Pr Justin Boddey
金额:
$27.27万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
在任何一年中,世界上都有高达10%的人口患有疟疾,超过100万人将死于这种疾病。这种毁灭性的疾病是由寄生虫恶性疟原虫感染和破坏我们的红细胞。受感染的红细胞被寄生虫极大地改变,因此它们可以进食并避免被人体免疫系统清除。我们希望研究红细胞修饰过程,并评估其作为抗疟疾药物的潜在靶点。
英文摘要
Up to 10% of the world's population will suffer from malaria in any given year and for over a million this disease will be fatal. This devastating disease is caused by the parasite Plasmodium falciparum that infects and destroys our red blood cells. Infected red cells are greatly modified by the parasites so they can feed and avoid elimination by the human immune system. We wish to investigate the red blood cell modification process and assess it as a potential target for anti-malarial drugs.
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会议论文
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : GNT1139153
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项目类别:Project Grants
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资助金额:$84.84万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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批准号:nhmrc : 1139546
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项目类别:Project Grants
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资助金额:$43.57万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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批准号:nhmrc : GNT1139546
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项目类别:Project Grants
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资助金额:$64.44万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : 1139153
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项目类别:Project Grants
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资助金额:$57.36万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : GNT1135421
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项目类别:Development Grants
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资助金额:$68.39万
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财政年份:2018
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负责人:A/Pr Justin Boddey
-
依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : 1135421
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项目类别:Development Grants
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资助金额:$46.24万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Functional genomics of malaria liver infection and transmission
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批准号:nhmrc : 1123727
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项目类别:Career Development Fellowships
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资助金额:$32.12万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Functional genomics of malaria liver infection and transmission
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批准号:nhmrc : GNT1123727
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项目类别:Career Development Fellowships
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资助金额:$47.01万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Effector export in P. falciparum infected human erythrocytes
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批准号:nhmrc : 1121178
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项目类别:Project Grants
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资助金额:$72.85万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Effector export in P. falciparum infected human erythrocytes
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批准号:nhmrc : GNT1121178
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项目类别:Project Grants
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资助金额:$106.69万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Role of exported proteins in malaria parasite development in the liver
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批准号:nhmrc : 1049811
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项目类别:Project Grants
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资助金额:$34.71万
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财政年份:2013
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负责人:A/Pr Justin Boddey
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依托单位:
Function and inhibition of Plasmepsin V in targeting malaria virulence proteins into human erythrocytes
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批准号:nhmrc : 1010326
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项目类别:Project Grants
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资助金额:$27.2万
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财政年份:2011
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负责人:A/Pr Justin Boddey
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依托单位:
characterisation of P. Flaciparum erythrocyte-targeted proteins
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批准号:nhmrc : 461281
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项目类别:Early Career Fellowships
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资助金额:$18.8万
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财政年份:2007
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负责人:A/Pr Justin Boddey
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依托单位:
海外基金