Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)

神经精神病学表型组学联盟(CNP)通过组装 一个跨学科的研究团队，以解决行为研究中尚未解决的主要挑战 精神错乱。CNP利用了表型组学的新学科--对人类表型的系统研究 在全基因组水平上--通过整合基础、临床和信息科学。神经精神障碍 具有巨大的公共卫生意义，目前基础和 用于研究这些疾病的临床研究策略。CNP打破了人为的界限 通过研究不同诊断中与大脑相关的重要表型， 并将基础科学和临床科学结合在同一项目中。CNP进一步侧重于 开发新的分析工具，在全基因组范围内研究复杂的多变量表型，以及 多层次图形可视化、表示和测试的信息学方法 跨学科的假设跨越了从基因组到综合症的概念。CNP由8个部分组成 由代表不同学科的52名调查人员领导的小组。CNP团队将执行 由两个P30核心和这个U54协调中心支持的五个联锁R01项目。U54 包括：(1)管理小组；(2)将协作完成的执行运营团队 联合体范围内的日常规划、预算管理和评估活动，以确保最佳 研究项目和核心之间的整合；(3)指导委员会一年两次审查 关于关键战略方向和资源分配的进展和具有约束力的投票；和(4)外部 咨询委员会提供年度评价审查，通过向 指导委员会和执行运营团队。互动创新将通过以下方式进一步推动 邀请外部专家参加的年度务虚会；一系列其他知识分享活动；以及 概念试点项目计划。U54小组还将管理数据共享和传播活动 确保CNP的概念和数据产品作为 向国际研究界提供资源。

The Consortium for Neuropsychiatric Phenomics (CNP) advances the NIH Roadmap Initiative by assembling an interdisciplinary research team to address major unsolved challenges in research on behavioral disorders. The CNP leverages the newdiscipline of phenomics - the systematic study of human phenotypes on a genome-wide level - by integrating basic, clinical and information sciences. Neuropsychiatric disorders have enormous public health significance, and there is currently a broad chasm between the basic and clinical research strategies used to study these disorders. The CNP breaks down artificial boundaries between psychiatric syndromes by studying important brain-relevant phenotypes across different diagnoses, and by combining basic and clinical sciences within the same projects. The CNP further focuses on developing novel analytic tools to study complex multivariate phenotypes on a genome-wide scale, and informatics approaches for the graphical visualization, representation and testing of multi-level interdisciplinary hypotheses spanning concepts from genome to syndrome. The CNP comprises 8 components led by a team of 52 investigators representing diverse disciplines. The CNP team will execute five interlocking R01 projects supported by two P30 cores and this U54 Coordinating Center. The U54 comprises: (1) an Administrative Group; (2) an Executive Operations Team that will collaboratively complete day-to-day consortium-wide planning, budget management, and evaluation activities to assure optimal integration among the research projects and cores; (3) the Steering Committee for twice-yearly reviews of progress and binding votes on critical strategic directions and resources allocations; and (4) an External Advisory Board to provide annual evaluative review, guiding performance through recommendations to the Steering Committee and Executive Operations Team. Interaction and innovation will be further promoted by annual retreats with invited external experts; a series of other knowledge-sharing activities; and a proof-of- concept pilot project program. The U54 team will also manage data sharing and dissemination activities consortium-wide, ensuring that the conceptual and data products of the CNP are freely available as a resource to the international research community.