HUMAN ANTIBODY CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 A.具体目标（试点项目）： + 为初级研究人员确定杰出的免疫学科学机会 + 为之前的COBRE调查人员提供启动资金，以生成额外的初步数据，从而申请其他资金来源。 B。研究和结果： 我们发现了一个机会，可以协助为发展一个额外的核心设施提供资金。在与EAC充分讨论后，创建了人抗体核心。以下描述了新创建的人抗体核心的具体活动，该核心由帕特里克威尔逊博士领导，直到他在2008年初夏离开。威尔逊博士在这项新技术的开发中发挥了重要作用。然而，核心关键人员仍然保留，琳达汤普森博士在肯尼斯史密斯博士的协助下担任该核心的领导，肯尼斯史密斯博士是描述该方法的最初手稿（Nature 2008）以及最近在Nature Protocols上发表的描述该方法的共同第一作者。通过开发这一核心，我们不仅可以为COBRE研究人员提供令人兴奋的新技术，还可以为这些研究人员提供该领域领先的专业知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims (for pilot projects): + To identify outstanding immunologic scientific opportunities for junior investigators + To provide start-up funds for previous COBRE investigators to generate additional preliminary data to apply for alternative funding sources. B. Studies and Results: We identified an opportunity to assist in the funding for the development of an additional core facility. After discussing thoroughly with the EAC, a human antibody core was created. Below describes the specific activities of the newly created Human Antibody Core, which was led by Dr. Patrick Wilson, until his departure in early summer 2008. Dr. Wilson was instrumental in the development of this new technology. However, the core key personnel have remained and Dr. Linda Thompson has assumed leadership of this core with the assistance of Dr. Kenneth Smith who was the co-first author on the initial manuscript describing this methodology (Nature 2008) as well as the recent publication in Nature Protocols describing this methodology. Through the development of this core, we can not only provide our COBRE investigators with an exciting new technology but also provide these investigators access to leading expertise in this area.