Novel Approaches for the Control of Microbial Pathogens

描述(由申请者提供)：要求提供五年的支持，以创建一个教师发展计划，使在堪萨斯州的三个博士授予机构(堪萨斯州劳伦斯大学的KU和堪萨斯城的KU医学院，以及堪萨斯州立大学)参与研究的初级教师在获得NIH资助方面变得更具竞争力，并招聘能够开发新研究项目的高级教师。将建立一个由Narayan博士和个人项目导师组成的强大的指导计划，他们都是成熟的调查人员，一个旨在帮助Cobre成员准备手稿和赠款的写作计划，以及一个每年两次审查所有项目进展的外部咨询委员会。在本项目的最后一年，已经建立了五个核心，一个是行政核心，一个是写作核心，三个是技术核心，以加快新的研究方案。科布雷以FTE和三个技术核心的新研究设备的形式得到了广泛的新机构支持。研究主题集中在旨在抑制病原微生物复制的基本和翻译机制上。研究将集中在识别微生物基因和基因产品，这些基因和基因产品对它们的复制和作为治疗目标的使用具有开创性作用。Cobre的翻译部分将致力于使用纳米颗粒作为体内输送的载体进行基因治疗。Cobre的资助将用于支持四名初级教员和一名高级教员的三年项目，用于加强三所院校新教师招聘方案的资金，以及用于进一步招聘可能有助于开发新研究项目的高级教师的资金。资金还将用于运营由最先进的流式细胞仪、信号转导和Luminex技术组成的三个技术核心，这将促进对感染引起的宿主反应基因产品的快速分析。目前选定的教员的项目是基于科学价值、外部咨询委员会成员的审查，重点是与其他项目的互补互动，发展到由高级教员领导的新研究项目的潜力，以及获得NIH资助的可能性。其中两个技术核心将由两名教职员工指导，他们之前得到了科布雷的支持，每人获得了两笔NIH拨款。新的项目是为了回应新的RFA，该项目建议招聘能够帮助开发和领导新研究项目的高级教员。已经招聘了一名这样的高级教员。最后，新计划是基于我们的记录，11名调查人员在前任科布雷的支持下，总共获得了16笔校外赠款。11人中有8人获得了12项国家卫生研究院的拨款。

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three Ph.D. granting institutions in Kansas (KU at Lawrence and the KU School of Medicine in Kansas City, and Kansas State University) to become more competitive for securing NIH grant support and to recruit senior faculty who could develop new research programs. A strong mentoring program comprised of Dr. Narayan and individual Project mentors, all of whom are established investigators, a writing program designed to assist COBRE members in preparation of manuscripts and grants, and an external advisory committee who will review progress of all Projects twice annually will be established. Five Cores, one administrative, one focused on writing, and three technical, have already been established in the final year of the present COBRE to expedite the new research program. The COBRE has received extensive new institutional support in the form of FTEs and new research equipment in the three technical Cores. The research theme is centered on basic and translational mechanisms aimed at inhibiting replication of pathogenic microbes. Studies will be focused on identification of microbial genes and gene products that have a seminal role in their replication and use of these as targets for therapy. The translational portion of the COBRE will be dedicated to use of gene therapy using nanoparticles as vectors for delivery in vivo. The COBRE support will be used to support three-year Projects of four junior faculty and one senior faculty, funds for enhancement of recruitment packages of new faculty at the three institutions, and funds for further recruitment of senior faculty who could contribute to development of new research programs. Funds will also be used to operate the three technical Cores comprised of state-of-the-art flow cytometry, signal transduction, and Luminex technology, which will facilitate rapid analysis of host response gene products resulting from infection. The Projects of currently selected faculty were based on scientific merit, review by External Advisory Committee members, with a focus for complementary interaction with other Projects, potential for development into new research programs headed by senior faculty, and likelihood for receiving NIH grant support. Two of the technical Cores will be directed by two faculty members who were previously supported by the COBRE and who have each secured two NIH grants. The new program was developed in response to the new RFA that suggested recruitment of senior faculty who could help develop and head new research programs. One such senior faculty has already been recruited. Finally, the new program has been based on our track record in which eleven investigators supported by the previous COBRE have secured a total of 16 extramural grants. Eight of the eleven have secured 12 NIH grants.