Molecular Analyses and Interventions for Biodefense and Emerging Pathogens

描述(申请人提供)：我国检测、预防和打击生物恐怖主义和新出现的传染病的能力取决于通过对致病微生物和人类免疫系统对它们的反应进行生物医学研究而产生的技术。国家过敏和传染病研究所(NIAID)建立了RCE网络，即生物防御和新出现传染病英才研究中心，以了解微生物病原体导致人类疾病的分子机制。掌握了这些知识，就可以开发旨在预防、诊断和治疗由生物恐怖主义制剂或新出现的病原体(NIAID A-C类制剂)引起的疾病的产品。我们在这里介绍五大湖(区域V)区域经济的竞争性更新申请，简称GLRCE。GLRCE\S是由伊利诺伊州、印第安纳州、密歇根州、明尼苏达州、俄亥俄州和威斯康星州的研究机构组成的联盟。GLRCE由其在芝加哥大学的管理核心组织，包括该地区所有一流的研究机构，包括阿贡国家实验室、巴特尔纪念研究所、伊利诺伊州立大学、印第安纳大学、洛约拉大学、梅奥诊所、威斯康星医学院、密歇根州立大学、圣母大学、西北大学、俄亥俄州立大学、普渡大学、芝加哥大学、辛辛那提大学、伊利诺伊大学、密歇根大学、明尼苏达大学和威斯康星大学。除了对生物防御产品的研究外，GLRCE还提供专业知识、教育和实验室基础设施网络，在生物防御和其他传染病紧急情况下为国家服务。GLRCE提出了一项针对公共卫生官员的教育计划，以及博士后和教职员工层面的科学卓越培训计划。GLRCE的研究和培训由一个机制管理，该机制涉及对科学卓越和转化目标的持续审查、机构间咨询委员会和外部科学咨询机构。 相关性：国家过敏和传染病研究所(NIAID)建立了RCE网络，以了解微生物病原体导致人类疾病的分子机制。掌握了这些知识，就可以开发旨在预防、诊断和治疗由生物恐怖主义制剂或新出现的病原体(NIAID A-C类制剂)引起的疾病的产品。 战略管理计划/行政核心：战略计划和管理(SMP Leader，O.Schnewind) 战略管理计划描述：大湖区卓越中心(GLRCE)的行政核心将由其主任、联席主任Olaf Schneewind博士、Bernard Roizman博士和副主任Navneet Bhasin博士领导。该核心旨在确保GLRCE及其所有27个附属机构的财务和行政完整性。核心项目的目的是保持项目的科学、客观和无偏见的指导和协调；使区域研究中心管理层能够发现机会并吸引智力和基础设施资源；创造一个开放和灵活的环境，对第五区域内外的新发展作出快速反应；监测全球区域研究中心所有活动朝着其目标的进展情况；招募合格的妇女和少数群体进入生物防御研究；并对从基础研究到医学研究再到第一反应人员等所有群体的需求作出反应。核心机构的组织将调查人员与制药和生物技术公司以及联邦、州和地方机构联系起来，以促进翻译研究并促进核心设施的最大限度利用。GLRCE确定了监测和自我评估其研究活动的机制，以及确定和应对新机会的机制。在发生生物防御紧急情况时，GLRCE行政核心将迅速调整其活动和资源，以协助地方和国家的响应努力，并促进与其参与者及其各自社区的顺畅沟通。GLRCE以委员会为基础的管理方案及其基于网络的协作工具将确保信息从上到下流动，反之亦然。 相关性：该核心旨在确保GLRCE及其所有附属机构的财务和行政完整性。核心的目的是保持对项目的科学、客观和无偏见的指导和协调；使区域经济中心管理层能够发现机会并吸引智力和基础设施资源。

DESCRIPTION (provided by applicant): Our nation's ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and the human immune system's response to them. The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, i.e. the Research Centers of Excellence for Biodefense and Emerging Infectious Diseases, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents). We present here the Competitive Renewal Application of the Great Lakes (Region V) RCE, abbreviated GLRCE. The GLRCE\s a consortium of research institutions in Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin. Organized by its Administrative Core at the University of Chicago, GLRCE includes all premier research institutions in this region, which are Argonne National Laboratory, Battelle Memorial Institute, Illinois State University, Indiana University, Loyola University, Mayo Clinic, Medical College of Wisconsin, Michigan State University, Notre Dame University, Northwestern University, Ohio State University, Purdue University, University of Chicago, University of Cincinnati, University of Illinois, University of Michigan, University of Minnesota, and the University of Wisconsin. In addition to research on biodefense products, the GLRCE provides a network of expertise, education and laboratory infrastructure that serves the nation during biodefense and other infectious disease emergencies. The GLRCE proposes an educational program for public health officials as well as training programs for scientific excellence at the post-doctoral and faculty level. Research and training at the GLRCE is governed by a mechanism involving ongoing review of scientific excellence and translational goals, inter-institutional advisory boards and external scientific advisory bodies. RELEVANCE: The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents). STRATEGIC MANAGEMENT PLAN/ADMINISTRATIVE CORE: Strategic Plan and Management (SMP Leader, O. Schneewind) STRATEGIC MANAGEMENT PLAN DESCRIPTION: The Administrative Core of the Great Lakes Regional Center of Excellence (GLRCE) will be led by its Director, Dr. Olaf Schneewind, Co-Director, Dr Bernard Roizman and Associate Director Navneet Bhasin, PhD. The core is designed to assure financial and administrative integrity of the GLRCE and all of its 27 affiliated institutions. The purpose of the core is to maintain scientific objective and bias-free direction and coordination of the projects; enable the RCE management to identify opportunities and to attract intellectual and infrastructural resources; create an open and flexible environment to respond quickly to new developments within and outside of Region V; monitor progress of all GLRCE activities toward their goals; recruit qualified women and minorities into biodefense research; and remain responsive to the needs of all its constituencies, ranging from basic research, to medical research to first responders. The organization of the core links investigators with pharmaceutical and biotech companies, as well as federal, state and local agencies to foster translational research and promote maximal use of the core facilities. The GLRCE has defined mechanisms for monitoring and self-evaluation of its research activities, as well as identifying and responding to new opportunities. In case of a biodefense emergency, the GLRCE administrative core will rapidly realign its activities and resources to assist local and national response efforts and facilitate fluent communications with its participants and their respective communities. The committee based management scheme of the GLRCE, and its web-based collaboration tools will ensure information flow from top to bottom and vice-versa. RELEVANCE: The core is designed to assure financial and administrative integrity of the GLRCE and all of its affiliated institutions. The purpose of the core is to maintain scientific objective and bias-free direction and coordination of the projects; enable the RCE management to identify opportunities and to attract intellectual and infrastructural resources.