CTSU resubmission: Proposal to increase capacity for methodological improvements in clinical trials

牛津大学？牛津大学的临床试验服务部门已经为牛津大学、英国其他地方和国际上的大量研究小组提供了主要临床试验不同阶段（设计、实施、分析和解释）的方法学建议。它旨在提高这些试验的质量（例如，更快地招募更多患者;更好的数据质量和研究实施），以便它们产生关于治疗对死亡率和主要发病率影响的更可靠证据。技术支助股将利用MRC中心的资金加强其在两个主要领域的领导作用。第一，为临床专家提供设计和进行试验（主要是血管和肿瘤疾病）的指导;第二，开发高效和安全的信息技术系统，以促进大规模试验的进行。来自更好的试验的更可靠的证据应该会导致公共卫生的实质性改善。

Oxford University?s Clinical Trial Service Unit already provides methodological advice across the different phases of major clinical trials (design, conduct, analysis and interpretation) to a large number of research groups in Oxford, elsewhere in the UK and internationally. It aims to improve the quality of these trials (e.g. more patients recruited more rapidly; better data quality and study conduct) in order that they generate more reliable evidence about the effects of treatments on mortality and major morbidity. MRC hub funding would be used by the CTSU to increase its leadership role in two main areas. Firstly, providing guidance to clinical experts on the design and conduct of trials (chiefly in vascular and neoplastic diseases); and, secondly, developing efficient and secure IT systems to facilitate the conduct of large-scale trials. More reliable evidence from better trials should lead to substantial improvements in public health.