TRAINING IN CANCER THERAPEUTICS

描述（由申请人提供）：本提案来自南卡罗来纳州医科大学（MUSC）和罗林斯癌症中心，请求支持博士后研究员癌症治疗学的跨学科研究培训计划。它旨在培养具有生物医学科学背景的有前途的年轻科学家，特别强调癌症的管理以及开发针对特定癌症的新型疗法所需的实验策略，方法和技术。毫无疑问，未来几十年，我们对癌症治疗所涉及的分子（化学和生物）的结构和功能的理解将取得更快的进展。这些见解的成功应用将允许开发新的治疗方法来治疗和预防癌症。这些进步将需要训练有素、精力充沛和富有成效的科学家，他们有能力在生理环境中理解和操纵分子事件。这些是我们的目标是通过这个培训计划的综合博士后组成部分开发的个人类型。导师资格的教师是根据他们与癌症治疗相关的研究兴趣，积极的NIH研究支持，持续的合作，成功的培训和指导经验，以及对博士后培训的承诺而选择的。24名成员包括18名教授，2名副教授，4名助理教授。他们有很强的出版记录，资金充足。十九（80%）持有NCI研究赠款。他们代表了2个学院的9个部门（生物化学，生物统计学，细胞生物学，医学，微生物学，病理学，药理学，医学院的外科学，药学院的药学科学）。项目主任和联合主任由项目指导委员会和小分子和基因治疗领域杰出专家组成的外部咨询委员会协助。培训计划的关键组成部分是指导研究经验，提供癌症的广泛视角的必修课程，负责任地进行研究，选修课程，期刊俱乐部，研讨会，区域和国家会议上的演讲以及专业发展活动所需的培训。项目评估是培训项目的一个强项。

DESCRIPTION (provided by applicant): This proposal from the Medical University of South Carolina (MUSC) and the Rollings Cancer Center requests support for an interdisciplinary research training program in cancer therapeutics for postdoctoral fellows. It is designed to train promising young scientists with backgrounds in the biomedical sciences with special emphasis on the management of cancer and the experimental strategies, approaches, and technologies necessary to develop novel therapeutics targeting specific cancers. Future decades will undoubtedly see even more rapid advances in our understanding of the structure and function of molecules (both chemical and biological) involved in cancer therapy. Successful application of these insights will permit development of novel therapeutic approaches to the treatment and prevention of cancer. Such advances will require well-trained, energetic, and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals we aim to develop through the integrated postdoctoral components of this training program. The Mentor-eligible Faculty Members were selected based on their research interests related to cancer therapeutics, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to postdoctoral training. The 24 members include 18 professors, 2 associate professors, and 4 assistant professors. They have strong publication records and are well funded. Nineteen (80%) hold NCI research grants. They represent 9 departments in 2 colleges (Biochemistry, Biostatistics, Cell Biology, Medicine, Microbiology, Pathology, Pharmacology, and Surgery in the College of Medicine, and Pharmaceutical Sciences in the College of Pharmacy). The Program Director and co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of small molecule and gene therapy. Key components of the training program are the mentored research experience, a required course providing a broad perspective of cancer, required training in responsible conduct of research, elective courses, journal clubs, seminars, presentations at regional and national conferences, and professional development activities. Program evaluation is a strength of the training program.