TRAINING IN MOLECULAR PATHOGENESIS OF MICROBIAL DISEASES

描述（由申请人提供）：这个继续培训计划的主要目标是为研究生和博士后研究员提供一流的培训经验，为从事科学研究，特别是生物医学机构的竞争力，独立调查员的职业做准备。作为这一目标的一部分，我们将招募有才华和积极性的学生和博士后研究员，致力于生物医学研究。在分子发病机制领域需要新的科学家，因为未来在预防和治疗新的、复活的和耐药的感染因子方面的成功将需要对发病机制的分子基础的复杂理解。该培训计划的重点是了解发病机制的分子机制，宿主-微生物相互作用，以及使用分子生物学，基因组学和生物信息学技术来研究发病机制。该培训计划由研究顾问单独指导，并由计划管理委员会整体指导。培训包括严格的实验室研究，每周研讨会，当地会议和高级课程。一个主要的优势是来自4个部门的10名资金充足的项目教师的研究项目的质量，他们在当前感兴趣的许多领域进行了富有成效和充满活力的研究工作。分子发病机制组是高度互动的，学员定期接触细菌（淋球菌，专性厌氧菌，假单胞菌，螺旋体，葡萄球菌，链球菌），原生动物（阿米巴，锥虫），真菌（隐球菌，肺孢子虫）和病毒（巨细胞病毒，肝炎，疱疹病毒）病原体使用全方位的现代分子技术的研究领域。该培训计划还受益于VCU医学院强大的研究生课程。学员受益于教师的积极参与，交流他们的工作经验，以及优秀的核心设施，所有这些都为培养下一代分子发病机制研究人员提供了极好的环境。

DESCRIPTION (provided by applicant): The major goal of this continuing training program is to provide graduate students and postdoctoral fellows with a first-rate training experience in preparation for careers as competitive, independent investigators in scientific research, particularly at biomedical institutions. As part of this goal, we will recruit talented and motivated students and postdoctoral fellows that are dedicated to biomedical research. New scientists are needed in the area of molecular pathogenesis because future success in the prevention and treatment of new, resurgent, and antibiotic-resistant infectious agents will require a sophisticated understanding of the molecular basis of pathogenesis. The training program focuses on understanding molecular mechanisms of pathogenesis, host-microbe interactions, and the use of molecular biology, genomic and bioinformatic technology to study pathogenesis. This training program is directed individually by research advisors and overall by a program governance committee. Training includes rigorous laboratory research, weekly seminars, local meetings, and advanced courses. A major strength is the quality of the research programs of the 10 well-funded program faculty members from 4 departments who have productive and energetic research efforts in numerous areas of current interest. The Molecular Pathogenesis Group is highly interactive, and trainees are regularly exposed to diverse areas of research on bacteria (gonococci, obligate anaerobes, pseudomonades, spirochetes, staphylococci, streptococci), protozoan (amoebae, trypanosomes), fungal (Cryptococcus, Pneumocystis), and viral (cytomegalovirus, hepatitis, herpesvirus) pathogens using the full range of modern molecular techniques. The training program also benefits from the presence of a strong graduate program in the School of Medicine of VCU. Trainees benefit from vigorous faculty involvement, experiences in communicating their work, and excellent core facilities, all of which provide a superb environment for training the next generation of researchers in molecular pathogenesis.