Chemistry-Biology Interface Training Grant

描述(由申请人提供)：这一化学-生物学接口的博士前培训项目涉及来自明尼苏达大学三个系的29名培训人员：化学、药物化学和生物化学、分子生物学和生物物理学(BMBB)。它寻求为其受训人员提供跨越化学和生物传统学科界限的研究培训体验。常见的研究主题包括：生物催化剂和双分子设计(Distefano，Kauzlauskus，Lipscomb，Ohlendorf，Schmidt-Dannert，Wackett，Wagner，Wilmot，York)，治疗药物(Amin，Bernlohr，Distefano，Georg，Hoye，Mansky，Sturla，Tretyakova，Wagner，Xing)，疾病化学(Arriaga，Bernlohr，Mansky，Murphy，Sturla，Tretyakova，Takova，Sturla，Tretyakova，Wagner，Walters，Takova，Thomas，Vegters)，金属生物化学(Amin，Lipscomb，Murphy，Ohlf，Pierre，Piert，York)，以及生物分析/生物化学(Arriaga，Walser，Griffin，Haynes，Pierre，Taton，Takova，Thomas，Vegters)。培训教员的研究小组都得到了很好的支持和装备。有广泛的设施用于多肽和寡核苷酸的合成、生物发酵、质谱分析、X射线结晶学、核磁共振和计算。该方案每年向8名受训人员提供支助，每名受训人员提供为期两年的支助。未来的受训者通常拥有化学、生物化学或油学方面的本科学位。预计他们将在化学以及分子生物学和生物化学方面获得彻底的基础。该培训计划的重点是解决生物系统中的合成/机械问题的研究问题，目的是在分子水平上理解和影响关键问题。这一培训计划的明确特点将是让一流的学生成长为在他们的主要兴趣领域和互补领域都有成就的专业人员。学生将从化学和生物的必修课程菜单中进行选择。此外，实验室轮换、化学生物学座谈会、年度研讨会、期刊俱乐部和联合小组会议将丰富学员的毕业经验。相关性：CBITG培训员及其受训人员共同开展与当前公共卫生重要问题有关的基本问题的研究。这些包括了解癌症是如何在细胞中启动的，肥胖和糖尿病是如何发展的，肌肉是如何工作的，设计和开发针对癌症、艾滋病毒和阿尔茨海默氏症的新药和检测探针，以及了解化学物质是如何在环境中分解的。

DESCRIPTION (provided by applicant): This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research training experience to its trainees that cross the traditional disciplinary boundaries of Chemistry and Biology. Common research themes include: Biocatalysts and Bimolecular Design (Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), Therapeutic Agents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing), Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all well supported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis, biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-year period. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry or oiology. They will be expected to obtain thorough grounding in chemistry, as well as molecular biology and biochemistry. The particular emphasis of this training program is a focus on research problems that address synthetic/mechanistic questions in biological systems, with the goal of understanding and influencing key at the molecular level. The defining characteristic for this training program will be to allow first-rate students to grow into accomplished professionals both in their primary area of interest and in a complementary field. Students will choose from a menu of required coursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium, an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience of the trainees. RELEVANCE: The CBITG trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and assay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are broken down in the environment.