NEUROENDOCRINE MEDIATION OF SOCIALLY INDUCED ANOVULATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 今年继续进行的研究评估了社会从属关系导致的心理社会压力对成年雌性恒河猴代谢、生殖和行为结果的影响。 此外，对编码5-羟色胺再摄取转运蛋白（5 HTT）的基因多态性的贡献进行了评估，因为其他研究表明，携带短启动子长度变体（s-变体）的一个或两个等位基因的个体比长启动子长度（l/l）纯合子的女性更容易受到心理社会压力的不良后果的影响。 在本年度，评价了雌二醇和孕酮对代谢激素和人体测量指标的影响。 无论社会地位和基因型如何，雌激素显著降低了所有雌性动物的体重和脂肪，而孕酮逆转了这种效应。 血清瘦素水平随体重变化而变化。 第二项研究评估了以下假设：促肾上腺皮质激素释放激素（CRH）受体类似物的给药将减少LH分泌，特别是在从属动物中。 女性接受雌二醇单独或与CRH受体类似物的组合。 下属女性，特别是那些与s-变异5 HTT基因型，是超敏感的负反馈作用，雌二醇对LH。 共同管理的CRH受体类似物增强雌二醇负反馈在所有女性，甚至在更大程度上在下属女性。 这些研究为患有压力诱发的不孕症的妇女提供了可能的治疗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have continued this year assessing the consequences of psychosocial stress, resulting from social subordination, on metabolic, reproductive, and behavioral outcomes I adult female rhesus monkeys. In addition, the contribution of polymorphisms in the gene that encodes the serotonin reuptake transporter (5HTT) was evaluated as other studies show individuals carrying one or both alleles of the short promoter length variant (s-variant) are more vulnerable to the adverse consequences of psychosocial stress than females homozygous for the long promoter length (l/l). During the current year, the effects of estradiol and progesterone on metabolic hormones and anthropometric measures were evaluated. Estradiol significantly reduced body weights and fat in all females, regardless of social status and genotype and this effect was reversed by progesterone. Serum leptin levels paralleled changes in body weight. A second study evaluated the hypothesis that administration of a corticotropin releasing hormone (CRH) receptor analogue would decrease LH secretion, particularly in subordinate animals. Females received estradiol alone or in combination with a CRH receptor analogue. Subordinate females, particularly those with the s-variant 5HTT genotype, were hypersensitive to the negative feedback action of estradiol on LH. Co-administration of the CRH receptor analogue enhanced estradiol negative feedback in all females, and even to a greater degree in subordinate females. These studies provide insights into possible treatment strategies for women suffering from stress-induced infertility.