General Clinical Research Center

超出空间 但前提是。 UVA GCRC的临床研究已进入第31个年头，我们要求在33-37年提供支持。我们的 GCRC在神经内分泌学、过敏、生殖医学、免疫治疗等方面拥有长期的优势 癌症和糖尿病。这些问题一直存在。在过去的两年里，我们吸引了一名新的GCRC干部 来自心脏病学、血管生物学和替代医学项目中心的研究人员在 护理学院。随着最近在我们的部门招聘新的研究密集型领导层， 心血管内科、血液学和肿瘤学，以及我们的精神病学和行为学系 在医学方面，我们预计我们的研究项目将继续增长和充满活力。在过去的两年里，我们 我们的核心化验程序也进行了重大升级，从而促进了样品吞吐量 &gt；每年100,000,000，同时腾出人员时间来实施其他分析服务。我们发起了一项新的 GCRC成像实验室允许研究糖尿病、胰岛素抵抗、 多器官包括心脏、肌肉和肾脏的PCOS和微血管灌注。 UVA GCRC一直享有出色的生产力记录(在过去4年中出版了170种出版物)。它的 运动、信息学和生物数学核心一直是国家领先的创新支持 临床调查。GCRC拥有由NIH资助的成熟调查人员的稳定核心，并正在 通过我们的教育和指导计划培养新一代熟练的临床医生 调查人员。我们特别为我们的CAP和K奖获得者感到自豪。 在过去的三年里，我们看到了门诊研究的增长(这是一个全国性的趋势)，同时 住院研究，特别是那些涉及24小时采血的研究，已经减少。我们有专业的- 积极开始与UVA保健系统合作，规划重新设计的GCRC，扩大空间和 为门诊患者提供更方便的服务，以适应当前和预计的使用情况。

EXCEED THE SPACE PROVIDED. Clinical investigation at the UVA GCRC is in its 31st year, and we request support for years 33-37. Our GCRC has longstanding strengths in neuroendocrinology, allergy, reproductive medicine, immunotherapy of cancer, and diabetes. These persist. In the past 2 years we have attracted a new cadre of GCRC investigators from Cardiology, vascular biology, and from the Center for Alternative Medicine program in the School of Nursing. With the recent recruitment of new research intensive leadership in our divisions of Cardiovascular Medicine, Hematology and Oncology, and our Department of Psychiatry and Behavioral Medicine, we anticipate continued growth and vitality of our research programs. In the past 2 years, we have also had major upgrades in our core assay program thereby facilitating sample throughput to >100,000/yr while freeing personnel time to implement additional analytical services. We have initiated a new GCRC imaging laboratory to allow studies of endothelial dysfunction in setting of diabetes, insulin resistance, and PCOS and microvascular perfusion in multiple organs including heart, muscle and kidney. The UVA GCRC has enjoyed an excellent record of productivity (>170 publications over the past 4 yrs). Its exercise, informatics and biomathematics cores have been national leaders in their innovative support for clinicalinvestigations. The GCRC enjoys a stable core of NIH-funded established investigators and is developing through our educational and mentoring programs another generation of skilled clinical investigators. We are particularly proud of our CAP and K award winners. During the last 3 years, we have seen (as has been a national trend) a growth in outpatient studies while inpatient studies, particularly those that have involved 24 hr blood sampling, have decreased. We have pro- actively begun working with the UVA Health System to plan a redesigned GCRC with expanded space and greater accessibility for outpatients that would accommodate current and projected usage.