General Clinical Research Center

描述（由申请人提供）：近年来，马里兰州（UM）医学院的研究经费显著增长，本年度总计3.41亿美元。作为该机构致力于维护和扩大基础设施以促进高质量临床和转化研究的一部分，我们于2002年在马里兰州大学医学中心建立了一个综合临床研究中心。GCRC的目标是为医学科学家提供临床研究的环境和资源，以确保研究和培训的最高质量。这个中心一直是一个显着的资产UM。GCRC整合了以前分散的临床研究企业，并产生了面向共享资源和更高标准研究的机构范围内的文化变革。 在最初的四年里，GCRC支持代表医学院和牙科和药学院内广泛学科的协议。GCRC设施对于开展许多项目至关重要，包括需要隔离病房以测试传染性病原体和活疫苗候选物的项目。五年前无法完成的项目现在可以通过GCRC的临床资源来完成。生物统计学和生物信息学核心的可用性被GCRC研究者广泛利用，并有助于无数研究的质量和管理。GCRC支持的基因组学核心设施已成为希望探索疾病遗传基础或病原菌遗传学的多个研究人员的大量订阅核心资源。GCRC研究受试者倡导者被高度视为研究伦理和后勤方面的咨询资源。GCRC已成为校园临床研究培训的重点。马里兰州的K30奖临床研究课程开发和路线图K12奖多学科临床研究职业发展的大学是不可分割的GCRC集成。 在这次更新中，我们利用节省成本的措施和机构支持，要求在三年内预算的总体增长不超过3%的通货膨胀率。在即将到来的赠款期间，我们预计UM临床和转化科学中心的规划和资金。

DESCRIPTION (Provided by Applicant): The University of Maryland (UM) School of Medicine has experienced remarkable growth in research funding in recent years, totaling $341 million in the current year. As part of the institution's commitment to maintaining and expanding infrastructure to facilitate high-quality clinical and translational research, we established a General Clinical Research Center in the University of Maryland Medical Center in 2002. The goal of the GCRC is to provide medical scientists with a setting and resources for clinical research that will ensure that research and training will be of the highest quality. This Center has been a remarkable asset to UM. The GCRC has consolidated a previously fragmented clinical research enterprise and produced an institution-wide cultural change toward shared resources and higher standards of research. In its first four years, the GCRC has supported protocols representing a wide range of disciplines within the School of Medicine and the Schools of Dentistry and Pharmacy. The GCRC facilities are essential to the conduct of numerous projects, including projects requiring an isolation ward for testing infectious agents and live vaccine candidates. Projects that could not have been done five years ago are now possible with the clinical resources of the GCRC. The availability of Biostatistical and Biolnformatics Cores is widely exploited by GCRC investigators and has contributed to the quality and management of innumerable studies. The GCRC-supported Genomics Core Facility has become a heavily subscribed core resource for multiple investigators who wish to explore the genetic basis of disease or the genetics of pathogenic bacteria. The GCRC Research Subject Advocate is highly regarded as a resource for consultation about the ethics and logistics of study conduct. The GCRC has become a focus for training in the clinical research on campus. The University of Maryland's K30 award for Clinical Research Curriculum Development and its Roadmap K12 award for Multidisciplinary Clinical Research Career Development are inextricably integrated with the GCRC. In this renewal, using cost-saving measures and institutional support, we have requested no overall increase in budget beyond a 3% increase for inflation for a 3-year period. During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center.