MACCHESS PROGRAM FOR NEW STATION FOR LONG WAVELENGTH CRYSTALLOGRAPHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项计划的主要重点是将CHESS F3弯曲磁铁站升级为灵活、双聚焦、高强度的X射线光束线，用于长波长蛋白质结晶学，包括SAD和微晶体研究。新功能的关键将是灵活的光学系统，该系统可以容纳用户可选择的窄能带通合成多层反射镜和聚焦元件，以优化特定的数据收集要求。长波长、低能量的X射线能力在今天的同步辐射光源中并不常见，因为大多数光束线都是为提供高通量而设计的。最好的高通量X射线源使用插入装置、摇摆器或波浪器作为其X射线源。插入设备确实会产生高X射线强度，但同时也会产生高热负荷。为了处理这些热负载，光束线设计了真空窗和石墨过滤器，以散热并保护存储环超高真空环境。然而，窗口吸收了长波长光，使得在波长低于8keV(1.5？)的情况下收集高通量、高信噪比的数据几乎是不可能的。我们的合作者对利用长波长的强大光束线表现出了极大的兴趣。1)辛戈拉尼小组(纽约州立大学北部医科大学)研究

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary focus of this initiative is to upgrade the CHESS F3 bend-magnet station to be a flexible, double-focused, high-intensity X-ray beamline for long wavelength protein crystallography, including SAD and microcrystal studies. Key to the new capabilities will be a flexible optics system that can accommodate a user-selectable choice of narrow energy-bandpass synthetic multilayer mirrors and focusing elements to optimize particular data collection requirements. Long wavelength, lower energy X-ray capabilities are not commonly available at synchrotron radiation sources today because most beamlines have been designed to deliver high flux. The best high-flux X-ray sources utilize insertion devices, wigglers or undulators, as their X-ray sources. Insertion devices do produce high X-ray intensities but they also produce high heat loads at the same time. To handle these heat loads, beamlines are designed with vacuum windows and graphite filters to dissipate the heat and protect storage ring ultra-high vacuum environments. The windows, however, absorb the long wavelength light and make it virtually impossible to collect high-flux, high signal-to-noise data at wavelengths below 8 keV (1. 5 ¿). Our collaborators have shown tremendous interest in utilizing a powerful beamline at long wavelengths. 1) The Cingolani group (SUNY Upstate Medical University) deals with the mechanisms of