NMR AND BIOCHEMICAL STUDIES OF BRAZZEIN WITH T1R2/T1R3 HETERORECEPTORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Brazzein是一种甜蛋白，存在于南美果树五子果中。该蛋白质与甜味受体T1R2-T1R3相互作用。为了了解它们的生物学意义及其与甜味受体的相互作用，我们需要了解甜味甜蛋白突变体和非甜味突变体的结构。这有助于深入了解它们的功能，并有助于了解它们与受体的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brazzein is a sweet protein found in South American fruit plant Pentadiplatra brazzeana Baillon. The protein interacts with the sweet receptor T1R2-T1R3. To understand their biological significance and interaction with the sweet receptor, we need to understand the structures of sweet brazzein and the non-sweet mutants. This gives insight into their function and help understand interaction with the receptor.