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INTRACELLULAR RNA TRAFFICKING

INTRACELLULAR RNA TRAFFICKING
细胞内 RNA 运输
批准号：
7956387
负责人：
JOHN H CARSON
金额：
$8.14万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-05-01 至 2010-04-30
来源：
https://reporter.nih.gov/project-details/7956387
关键词：
BindingCell modelCellsComplexComputer Retrieval of Information on Scientific Projects DatabaseFluorescenceFundingGrantIn VitroInstitutionLifeMapsMeasuresModelingNeuronsProcessRNAResearchResearch PersonnelResourcesSourceSpectrum AnalysisSurface Plasmon ResonanceSystemTechniquesUnited States National Institutes of Healthin vivotraffickingvirtual

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA trafficking is a complex process whereby specific RNAs are localized to particular subcellular compartments. Through a variety of in vivo and in vitro techniques we have delineated a molecular interaction map describing the RNA trafficking system in neural cells. We have measured quantitative parameters for each molecular interaction in RNA trafficking using surface plasmon resonance analysis in vitro and fluorescence correlation spectroscopy (FCS) and in live cells. Quantitative parameters are used in Virtual Cell models of RNA trafficking.
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Pathogenic consequences of expansions and deletions of CGG repeats in the FMR1 gene
Pathogenic consequences of expansions and deletions of CGG repeats in the FMR1 gene
VIRTUAL FCS
INTRACELLULAR RNA TRAFFICKING
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