Psychobiological investigation of the socioemotional functioning in autism

描述（由申请人提供）：自闭症目前被广泛认为是一种谱系障碍，受影响的个体有不同程度的社会和情感障碍。在目前的应用中，我们描述了自闭症的一个新的概念，以解释一些异质性。在应用中，提出了一种神经内分泌谱模型，其中情绪反应性，社会反应性和生物学指标相交以定义不同的亚型。调查涉及三个相互关联的社会情绪功能研究，利用几种分析方法，包括情绪唤醒和压力的生物学标记评估，复杂的行为观察技术，以及功能神经成像，以仔细探索自闭症儿童和非自闭症儿童的心理生物学特征。具体而言，在操场活动的同伴互动中，通过复杂的行为观察来评估自闭症儿童表现出的互动频率、持续时间和互动顺序。这些数据将与应激激素一起分析，以揭示行为和生物症状之间的关系。此外，我们将探索这些孩子在与不同的电脑和人类伙伴玩游戏时的大脑激活模式。预计这项对“现实世界”社会互动的全面研究将使我们能够揭示孩子的行为、生物特征和大脑活动之间有意义的联系，在与同伴玩耍之前、期间和之后。最终的目标是，这些结果将更好地告知我们对自闭症的理解，使我们能够提供个性化的生物和行为治疗。

DESCRIPTION (provided by applicant): Autism is currently widely viewed as a spectrum disorder with affected individuals having varying degrees of social and emotional disturbances. In the present application we describe a new conceptualization of autism in order to account for some of the heterogeneity. In the application, a neuroendocrine spectrum model is proposed in which aspects of emotional reactivity, social responsiveness and biological indices intersect to define distinct subtypes. The investigation involves three interrelated studies of socioemotional functioning utilizing several methods of analysis to include the assessment of biological markers of emotional arousal and stress, sophisticated behavioral observational techniques, and functional neuroimaging in order to carefully explore the psychobiological profiles of children with and without autism. Specifically, during peer interactions of a playground activity, sophisticated behavioral observation will be obtained to evaluate the frequency, duration and interactive sequences exhibited by children with autism. These data will be analyzed with stress hormones to uncover relationships between behavioral and biological symptom profiles. In addition, we will explore brain activation patterns in these children while they play games with different computer and human partners. It is anticipated that this comprehensive study of "real world" social interactions will allow us to uncover meaningful associations between the child's behavior, biological profiles and brain activity before, during and after play with peers. The ultimate goal is that these results will better inform our understanding of autism to allow us to provide individualized biological and behavioral treatments. PUBLIC HEALTH RELEVANCE: Autism is a spectrum disorder in which affected individuals have varying degrees of social and emotional disturbances. In the application, a model is proposed in which aspects of emotional reactivity, social responsiveness and biological measures are combined to form distinct subtypes. Social and emotional functioning of children with autism is explored using sophisticated behavioral observations of social interactions, measurement of stress hormones, and the study of brain activity in response to playing games during "real world" interactions to help us to better understand the variability of behavior, brain and hormones in children with autism.