REQUEST TO PURCHASE A 400 MHZ NMR SPECTROMETER

描述（由申请人提供）：位于圣刘易斯的华盛顿大学（WU）是美国顶尖的研究机构之一，并在其两个主要校区丹佛斯和医疗中心支持广泛的研究，这两个校区相距三英里。WU高分辨率核磁共振设备是该大学唯一的开放获取资源，用于溶液状态分析和结构NMR应用。二十多年来，它每年都为两个校区的40多个独立的化学，生物化学和生物医学研究小组提供服务。然而，由于NMR设施的整套仪器仅位于丹佛斯校园，吴的医学中心校园研究人员没有立即获得附近的NMR分析，因为现代，生物导向，合成化学的要求。这已被证明是一个重大的困难和实质性的阻碍正在进行的NIH资助的研究。为了解决这个问题，WU NMR设施要求NCRR SIG资助购买一台400 MHz NMR光谱仪，安装在WU医疗中心校园内。这是第一次，吴医学中心校园研究人员将有方便和立即获得这种强大的分析技术。本申请是在NIH资助的WU医学中心校园研究人员的敦促下编写的，他们需要显着增强对分析和结构NMR工具的访问。该提案要求资金244，680美元，加上内部配套资金80，000美元，足以购买所要求的仪器，400 MHz（9.4特斯拉）Varian公司。(Palo Alto）DirectDrive”系统。在过去十年中，核磁共振仪器技术的进步，特别是在超导磁体和杜瓦瓶设计以及数字控制和通信领域的进步，以适度的成本提供了非凡的光谱仪能力。DirectDrive”架构代表了瓦里安新一代的控制台技术，它利用了过去十年数字电子产品的巨大进步。在WU医学中心校园找到所需的仪器将立即显着受益于正在进行的NIH资助的研究计划，将解决方案状态NMR分析的多功能和强大的工具带入WU的生物医学研究者社区的心脏。

DESCRIPTION (provided by applicant): Washington University (WU) in St Louis is among the nation's top research institutions and supports extensive research at its two primary campuses, Danforth and medical center, which are separated from each other by a distance of three miles. The WU High Resolution Nuclear Magnetic Resonance Facility is the University's only open access resource for solution-state analytical and structural NMR applications. Each year for over two decades it has served in excess of 40 separate chemical, biochemical and biomedical research groups from both campuses. Nevertheless, because the NMR Facility's entire suite of instrumentation is located solely on the Danforth Campus, WU's medical center campus researchers have not had immediate nearby access to NMR analysis, as is required of modern, biologically oriented, synthetic chemistry. This has proven to be a significant hardship and substantive hindrance to ongoing NIH funded research. To address this problem, the WU NMR Facility requests NCRR SIG funding to purchase a 400 MHz NMR spectrometer to be located at the WU medical center campus. For the first time, WU medical center campus researchers will have convenient and immediate access to this powerful analytical technique. This application was written at the urging of established, NIH funded, WU medical center campus researchers who require significantly enhanced access to analytical and structural NMR tools. The proposal requests funds of $244,680, which combined with internal matching funds of $80,000 are sufficient to purchase the requested instrument, a 400 MHz (9.4 tesla) Varian, Inc. (Palo Alto) DirectDrive" system. Advances in NMR instrument technology during the past decade, in particular in the areas of superconducting magnet and dewar design, and digital control and communications, provide extraordinary spectrometer capabilities at modest cost. The DirectDrive" architecture represents a new generation of console technology from Varian, one that leverages the tremendous advances in digital electronics of the past decade. Locating the requested instrument at the WU medical center campus will immediately and significantly benefit ongoing NIH funded research programs, bringing the versatile and powerful tools of solution-state NMR analysis into the heart of WU's biomedical investigator community.