Upgrade of 600 MHz NMR spectrometer

描述（由申请人提供）：申请资金用于升级一台有12年历史的600 MHz磁共振光谱仪，配备Bruker Biospin AVANCE IIINMR控制台、四共振反检测QCI CryoProbe和SampleJet自动换样器。所要求的设备将安装在现有的布鲁克分光旋主动屏蔽14.1 T磁铁上。600兆赫核磁共振光谱仪的升级对于美国国立卫生研究院资助的光谱仪主要用户研究的特定目标和哥伦比亚大学建立其在生物科学、结构生物学和生物物理学以及临床研究方面现有优势的长期目标都是至关重要的。在600 MHz仪器上进行的研究范围从生物分子结构/功能的基础研究，例如涉及DNA修复，到正常和病理组织中生物标志物的分析，再到新型先导化合物的发现，再到药物应用。所要求的设备的三个组成部分中的每一个都提供了显著的性能改进，它们的整体将大大增强600 MHz核磁共振光谱仪进行这项研究的能力。

DESCRIPTION (provided by applicant): Funding is requested to upgrade a 12-year-old 600 MHz MR spectrometer with a Bruker Biospin AVANCE IIINMR Console, quadruple resonance inverse detection QCI CryoProbe, and SampleJet automated sample changer. The requested equipment will be installed on an existing Bruker Spectrospin actively shielded 14.1 T magnet. The requested upgrades of the 600 MHz NMR spectrometer are essential both to the particular aims of the NIH-funded research of the major users of the spectrometer and to the long-term goal of Columbia University to build upon its existing strengths in biological sciences, structural biology and biophysics, and clinical research. Research conducted on the 600 MHz instrument ranges from fundamental studies of structure/function of biomolecules, for example involved in DNA repair, to analysis of biomarkers in normal and pathological tissues, to discovery of novel lead compounds to pharmaceutical applications. Each of the three components of the requested equipment provides significant improvements in performance that in their entirety will dramatically enhance the capabilities of the 600 MHz NMR spectrometer to conduct this research.