Collaborations to Advance Research and Ethics (CURE)

描述(由申请者提供)：西北生物医学研究协会(NWABR)是一家促进对生物医学研究的理解和支持的非营利性组织，它将利用其在生物伦理学教师培训和课程开发方面的丰富经验及其成员研究组织的合作伙伴关系，开发一个高度协作和多方面的拓展计划，即“理解科学与伦理的合作(CURE)”。我们的长期目标包括增加公众对生物医学研究的性质以及科学和伦理关系的理解，特别强调转化性研究-将基础研究应用于临床疗法开发的过程。该项目的具体目标是：1)为中学和高中生命科学教育工作者提供教师专业发展和课程资源，目标是翻译研究的科学和伦理；2)为学生提供学习经验，增加他们对翻译研究和伦理的理解；3)传播通过CURE计划开发的资源和材料。以下活动将包括：1)一个名为“生物医学研究--科学与伦理学”的教师专业发展研讨会，其中包括在研究设施中与科学家共事，并与审查研究方案的个人进行讨论；2)为中学开发一个“研究诚信”课程，侧重于适用于科学行为、在研究中使用动物和进行人类临床试验的研究过程和伦理标准；3)为来自少数族裔背景的高三学生举办一个“生物医学研究员”计划，提供实验室访问、与科学家的互动，以及对研究过程的广泛概述。4)举办“青年伦理高峰会”，汇聚曾参与我们专业发展的教师的学生，参与与伦理学家和其他学生的互动讨论，并展示与生物伦理有关的项目。第二阶段的传播将通过与华盛顿大学合作开发在线教师课程、讲习班以及通过美国生物科学研究所的ActionBioscience网站等合作伙伴通过网络实现。项目评估将利用定性和定量的研究方法，包括实验组和控制组，以检查教师专业发展计划对学生学习的影响。 虽然普通公众享受着生物医学研究对健康的重要好处，但他们通常不知道产生新的治疗和治愈方法的过程，也不知道有助于确保负责任地进行研究的道德标准。例如，对于基础科学如何与药物和疗法的发展相关，为什么需要动物，或者临床试验是如何进行的，存在着相当大的误解。为了确保对研究企业的持续支持，有必要促进对生物医学研究过程的理解，并解决其伦理考虑问题。

DESCRIPTION (provided by applicant): The Northwest Association for Biomedical Research (NWABR), a non-profit organization that advances the understanding and support of biomedical research, will utilize its extensive experience in bioethics teacher training and curriculum development as well as the partnership of its member research organizations to develop a highly collaborative and multi-faceted outreach program, "Collaborations to Understand Science and Ethics (CURE)". Our long-term goals include increasing public understanding of both the nature of biomedical research and the relationship of science and ethics, with a special emphasis on translational research - the process of applying basic research to the development of clinical therapies. The specific aims of this project are to: 1) Provide teacher professional development and curricular resources for middle and high school life science educators that target the science and ethics of translational research, 2) Provide learning experiences for students that will increase their understanding of translational research and ethics, and 3) Disseminate the resources and materials developed through the CURE program. The following activities will be included: 1) A 'Biomedical Research-Science and Ethics' teacher professional development workshop that includes time with scientists in research facilities and discussions with individuals who review research protocols, 2) Development of a 'Research Integrity' curriculum for secondary schools focused on the research process and ethical standards that apply to scientific conduct, the use of animals in research, and human clinical trials, 3) A 'Biomedical Research Fellows' program for high school juniors from underrepresented minority backgrounds that provides laboratory visits, interactions with scientists, and a broad overview of the research process, 4) A 'Youth Ethics Summit' that brings together students of teachers who have participated in our professional development to participate in interactive discussions with ethicists and other students and to showcase projects related to bioethics. Dissemination in Phase II will be accomplished by the development of an online teacher course in collaboration with the University of Washington, workshops, and through the web via partners such as the American Institute of Biological Science's ActionBioscience site. Program evaluation will utilize both qualitative and quantitative research measures, including experimental and control groups to examine the impacts of the teacher professional development program on student learning. While members of the general public enjoy the vital health benefits of biomedical research, they are generally unaware of the process that generates new treatments and cures, or the ethical standards that help ensure that research is responsibly conducted. For example, there is considerable misunderstanding about how basic science relates to the development of drugs and therapies, why animals are needed, or how clinical trials are conducted. To ensure continued support for the research enterprise, it is necessary to promote understanding of the process of biomedical research and also to address its ethical considerations.