DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目旨在研究（a）猴子海马和嗅周corex功能的发展，（B）这些脑区早期损伤对记忆过程和社会联系成熟的长期影响，以及（c）与成人损伤相比，这些早期损伤导致的其他脑系统的解剖学重组。 在本年度，我们继续研究行为训练的猴子，我们已经准备好了新生儿海马损伤和他们的假手术对照，因为他们正在进入青春期和成年早期。 我们已经评估了他们的工作记忆能力，使用三种不同的记忆任务（会话独特的DNMS，自我排序和串行顺序任务），发现深刻的赤字，提示功能障碍的背外侧前额叶皮层（DLPFC）。 因此，我们开始了代谢PET研究，以评估DLPFC的功能，同时动物正在执行会话独特的DNMS。 我们还继续训练那些接受了新生儿嗅周皮层损伤的动物，并在它们成为青少年时对测量物体和空间识别记忆、社会互动和情绪反应的任务进行控制。 我们的主要动机是希望通过这样的研究，可以建立大脑对损伤的反应原理，最终发现减轻甚至消除损伤影响的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to investigate (a) the development of hippocampal and perirhinal corex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we have continued to study behaviorally trained monkeys that we have prepared with neonatal lesions of the hippocampus and their sham-operated controls as they are reaching adolescence and early adulthood. We have assessed their working memory abilities using three different memory tasks (session-unique DNMS, self-ordered and serial order tasks) and found profound deficit, suggestive of dysfunction in the dorsolateral prefrontal cortex (DLPFC). We thus began a metabolic PET study to assess functioning of the DLPFC while the animals are performing the session-unique DNMS. We have also continued the training of animals that had received neonatal lesions of the perirhinal cortex and their controls in tasks measuring object and spatial recognition memory, social interactions and emotional reactivity as they become juveniles. Our primary motivation is the hope that, through such research, principles of the brain's response to damage can be established that will lead ultimately to the discovery of ways in which the effects of damage can be alleviated or even eliminated.