NOVEL STRATEGIES FOR OVARIAN CANCER PREVENTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 卵巢癌研究的进展受到未能了解疾病病因的限制。 这在很大程度上是由于缺乏上皮性卵巢癌的自然模型影响妇女的主要形式以及大多数动物系统不能准确反映与卵巢癌风险相关的正常生物学因素（即年龄和卵巢功能）。 因此，由于无法确定适当的风险因素，预防战略的制定受到限制。 我们已经利用基因表达研究，以确定在培养的卵巢细胞中发现的基因表达的变化，从妇女与没有家族史的疾病，恒河猴模型将被用来评估改变这些“在风险”细胞的基因表达的方法，作为一种手段，以防止卵巢癌的妇女家族史的疾病。 此外，我们将使用非人灵长类动物作为模型来测试是否可以使用温和的洗涤剂消除大多数卵巢癌的来源，卵巢表面上皮，以永久降低卵巢癌的风险。 目前的研究表明，通过去污剂去除后6个月内，表面上皮不会再生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in ovarian cancer research are limited by a failure to understand the etiology of the disease. In large part this is due to the absence of a natural model for epithelial ovarian cancerthe predominant form affecting womenand an inability for most animal systems to accurately reflect the normal biological factors that have been associated with ovarian cancer risk (namely age and ovarian function). As a result, the development of preventive strategies is limited by an inability to identify appropriate risk factors. We have utilized gene expression studies to identify changes in gene expression found in cultured ovarian cells from women with versus without a family history of the disease, and the rhesus model will be used to evaluate methods of altering gene expression in these "at risk" cells as a means to prevent ovarian cancer in women with a family history of the disease. In addition, we will use the nonhuman primate as a model to test whether the source of most ovarian cancers, the ovarian surface epithelium, may be eliminated using mild detergent to permanently reduce ovarian cancer risk. Current studies indicate that the surface epithelium does not regrow within 6 months of removal via deteregent.