GENETIC LINKS TO ALCOHOLISM IN A NONHUMAN PRIMATE SPECIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是：(1)测试在临床研究中与酒精消耗量增加有关的行为和生理标记是否可以在猴子群体中测量，(2)测试猴子是否有证据表明这些行为/生理标记是可遗传的，以及(3)利用我们之前收集的每只猴子的基因数据进行连锁分析，以确定携带与临床人群中酒精中毒相关的表型遗传信息的染色体区域。被评估的表型包括：焦虑行为，酒精诱导的共济失调和脑脊液中5-羟色胺水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are: (1) to test whether behavioral and physiological markers that have been linked to increased consumption of alcohol in clinical studies can be measured in a population of monkeys, (2) to test whether there is evidence in the monkey that these behaviors/physiological markers are heritable, and (3) to utilize our previously collected genotypic data in each monkey for linkage analysis to identify chromosomal regions carrying genetic information about phenotypes linked to alcoholism in clinical populations. Phenotypes being assessed include: anxious behaviors, alcohol-induced ataxia and CSF serotonin levels in cerebrospinal fluid.