Development of a Cognitive Paradigm Ontology: BrainMap and BIRN Intergration

描述（由申请人提供）：本提案的目标是开发，评估和分发认知范式的领域本体，用于功能神经影像学社区的应用和使用。这个认知范式本体，CogPO，将通过整合两个知名的和已建立的数据库，功能成像生物医学信息学研究网络（FBIRN）人类成像数据库（HID）和BrainMap数据库来开发。CogPO的设计集中于可以直接观察到的东西：根据(1)呈现给受试者的刺激，(2)请求的指令和(3)返回的反应对每个范式进行分类。所有范式本质上都由这三个正交的组件组成，围绕它们形式化一个本体是描述范式的一种清晰而直接的方法。这种结构化的、定义良好的、通用的和受控的词汇表将能够表示FBIRN数据存储库中的认知范式，FBIRN数据存储库存储结构和功能成像数据集以供以后分析，而BrainMap存储功能成像文献的分析结果。该提案旨在与国家生物医学本体中心（NCBO）和神经信息学信息框架（NIF）进行强有力的合作。NCBO和NIF目前都没有寻求发展认知范式的本体论；因此，当前的建议是新颖的，不与任何现有的本体工作冲突，而是一个补充的努力。通过一系列的研讨会，CogPO开发人员将咨询领域专家（神经成像研究社区）、本体专家（NCBO）和BIRN本体任务组（OTF）。CogPO开发人员还计划通过神经成像信息学工具和资源交换中心（NITRC）允许整个神经成像社区的用户输入和反馈。该提案包括一个正式的社区接受已开发的本体的计划，以及在资助期结束前分发的Protigi-OWL格式的具体交付成果清单，不仅可以供FBIRN和BrainMap用户使用，还可以供整个神经影像学社区使用。我们的最终目标是设计CogPO，使其能够扩展到认知科学的更广泛的背景。公共卫生相关性：认知范式领域本体CogPO将促进以机器可读和机器可解释的方式描述认知实验范式，从而允许跨不同数据库和数据源进行通信和自动数据共享。这个本体论不仅可以被其他fMRI数据库采用，也可以被其他神经成像模式（例如脑电图或MEG数据）的档案采用，例如神经电磁本体论（NEMO），以及神经科学学会PubMed Plus等文献神经信息学工作。我们的最终目标是设计CogPO，使其能够扩展到认知科学的更广泛的背景。

DESCRIPTION (provided by applicant): The objective of this proposal is to develop, evaluate, and distribute a domain ontology of cognitive paradigms for application and use in the functional neuroimaging community. This cognitive paradigm ontology, CogPO, will be developed through the integration of two well known and established databases, the Functional Imaging Biomedical Informatics Research Network (FBIRN) Human Imaging Database (HID) and the BrainMap database. The design of CogPO concentrates on what can be observed directly: categorization of each paradigm in terms of (1) the stimulus presented to the subjects, (2) the requested instructions, and (3) the returned response. All paradigms are essentially comprised of these three orthogonal components, and formalizing an ontology around them is a clear and direct approach to describing paradigms. This structured, well-defined, common and controlled vocabulary will be capable of representing the cognitive paradigms in the FBIRN Data Repository, which stores structural and functional imaging datasets for later analysis, and in BrainMap, which stores analyzed results from the functional imaging literature. This proposal has been designed to include strong collaboration with the National Center for Biomedical Ontology (NCBO) and the Neuroinformatics Information Framework (NIF). Neither the NCBO nor the NIF currently seeks to develop an ontology of cognitive paradigms; thus, the current proposal is novel and does not conflict with any existing ontology efforts, but is a complementary endeavor. Through a series of workshops, CogPO developers will consult both the domain experts (the neuroimaging research community) and the ontological experts (NCBO) and the BIRN Ontology Task Force (OTF). CogPO developers also plan to allow user input and feedback from the entire neuroimaging community through the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). This proposal includes a formal plan for community acceptance of the developed ontology, complete with a list of concrete deliverables in Protigi-OWL format to be distributed by the end of the funding period, which can be utilized not only by FBIRN and BrainMap users, but also by the entire neuroimaging community. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences. PUBLIC HEALTH RELEVANCE: CogPO, a domain ontology of cognitive paradigms, would facilitate descriptions of cognitive experimental paradigms in ways that are machine-readable and machine-interpretable, to allow communication and automated data sharing across diverse databases and data sources. This ontology will be made available for adoption not only by other fMRI databases, but also for archives of other neuroimaging modalities (e.g., EEG or MEG data), such as the Neural ElectroMagnetic Ontologies (NEMO), and literature neuroinformatics efforts such as the Society for Neuroscience's PubMed Plus. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences.