Interdisciplinary Predoctoral Neuroscience Training Program

描述（由申请人提供）：我们的神经科学博士前培训计划为有兴趣从事生物和生物医学科学科学研究事业的博士前学生提供个性化，高质量的培训。在这个竞争性的更新，我们要求的位置，以支持六名学生在他们的头两年的研究生学习，他们完全从事他们的论文研究之前。这一水平的资金将资助约50%的培训补助金合格的博士前学生在他们的研究的头两年。我们计划每年招收10至12名学生参加神经科学研究生课程;在下一个资助期内，总入学人数将从目前的30-40名学生增加到约60名。我们计划的研究生接受广泛的多学科培训，涵盖从基因到认知的多个层次的探究，并强调概念，方法和对主要文献的复杂分析。我们的核心课程包括团队授课的研究生课程，研讨会和讲习班，为神经科学提供坚实的基础，并培养神经科学成功，独立研究职业所必需的技能，如有效的科学写作和口头陈述，科学审查过程的知识，以及道德培训。我们有成功的举措，让学生接触到转化和临床神经科学与我们的板凳到床边研讨会系列。与我们的精神病学同事合作，研究生有独特的机会与患有神经系统疾病的患者见面和交谈，包括强迫症，失语症，帕金森病和成瘾。平均而言，学生在我们的程序完成他们的博士学位在5.3年，和我们的大多数校友继续他们的职业生涯在学术或工业科学的职位。我们培养一个不受传统学科界限约束的环境，鼓励研究生在这些学科的令人兴奋的界面上工作。该培训计划目前包括26名主要参与教师，他们来自与布朗脑科学研究所相关的约100名科学家的大型社区。教师培训师来自八个不同的布朗大学部门，包括神经科学;认知，语言和心理科学;分子生物学，细胞生物学和生物化学;工程;精神病学和人类行为。他们是一群杰出而充满活力的神经科学家，共同涵盖了现代神经科学研究的范围：他们与各种各样的模式生物合作，从蠕虫到人类，并使用一系列令人印象深刻的现代神经科学技术，包括功能磁共振成像，机器人和神经修复术的应用，光遗传学，先进的体内和体外电生理记录，小鼠转基因，行为研究，神经元基因的分子操作、功能蛋白质组学和人类全基因组关联研究。我们鼓励和促进实验室之间的合作，以及在计算和翻译神经科学的研究，通常驻留在学科的接口。在布朗神经科学研究生课程的主要特点包括：在研究沿着卓越的教育和指导;跨学科和翻译研究的历史;和国家认可的实验室，研究生在研究过程中平等的合作伙伴的环境。 公共卫生相关性：这是Lipscombe教授的竞争性更新申请，用于资助布朗大学跨学科神经科学研究生项目的早期博士前学员。该培训方案为早期、无差别的学生在头两年的教学中提供资金。学生继续进行跨学科研究的26个教师的研究重点在神经科学的基础和临床问题之一的监督下。

DESCRIPTION (provided by applicant): Our predoctoral training program in Neuroscience provides individualized, high quality training to predoctoral students interested in pursuing scientific research careers in the biological and biomedical sciences. In this competing renewal we request positions to support six students in their first two years of graduate studies, before they fully engage in their dissertation research. This level of funding would fund about 50% of training grant eligible predoctoral students in the first two years of their studies. We plan to recruit 10 to 12 students to the Neuroscience Graduate Program each year; growing overall enrollment from currently 30-40 students to about 60 over the next funding period. Graduate students in our program receive broad, multi-disciplinary training that spans many levels of inquiry, from genes through cognition, and emphasizes concepts, methodologies, and sophisticated analysis of the primary literature. Our core curriculum consists of team- taught graduate courses, seminars, and workshops that provide a strong foundation in Neuroscience and develop skills that are essential for successful, independent research careers in neuroscience, such as effective science writing and oral presentation, knowledge of scientific review processes, and training in ethics. We have successful initiatives that expose students to translational and clinical Neuroscience with our Bench to Bedside seminar series. In collaboration with our colleagues in Psychiatry graduate students have the unique opportunity to meet and talk with patients suffering from diseases of the nervous system including those with Obsessive Compulsive Disorder, Aphasia, Parkinson's Disease, and Addiction. On average, students in our program finish their PhD in 5.3 years, and the majority of our alumni continue their careers in academic or industry science positions. We foster an environment unconstrained by traditional discipline boundaries and where graduate students are encouraged to work at the exciting interfaces of these disciplines. The training program currently includes 26 primary participating faculty drawn from a large community of ~100 scientists associated with the Brown Institute for Brain Science. Faculty trainers are drawn from eight different Brown University departments that include Neuroscience; Cognitive, Linguistic, and Psychological Sciences; Molecular Biology, Cell Biology, and Biochemistry; Engineering; and Psychiatry and Human Behavior. They are a distinguished and energetic group of neuroscientists that collectively cover the spectrum of modern neuroscience research: they work with a wide variety of model organisms, from worms to humans, and use an impressive array of modern neuroscience techniques, including functional MRI, applications of robotics and neuroprosthetics, optogenetics, advanced in vivo and in vitro electrophysiological recordings, mouse transgenics, behavioral studies, molecular manipulations of neuronal genes, functional proteomics, and human genome-wide association studies. We encourage and facilitate collaborations between labs as well as research in computational and translational neuroscience that typically reside at the interface of disciplines. Key features of the Neuroscience Graduate Program at Brown include: Excellence in research along with excellence in education and mentorship; a history of interdisciplinary and translational research; and an environment of nationally recognized labs where graduate students are equal partners in the research process. PUBLIC HEALTH RELEVANCE: This is a competing renewal application from Professor Lipscombe to fund early predoctoral trainees in the Interdisciplinary Neuroscience Graduate Program at Brown University. This training program funds early, undifferentiated students in their first two years of instruction. Students go on to carry out interdisciplinary research under the supervision of one of 26 faculty whose research focus on basic and clinical problems in neuroscience.