Biopsychosocial Relationships underlying Indoor Tanning Experience: Project BRITE

描述(申请人提供)：皮肤癌作为人类最常见的恶性肿瘤，是一个主要的公共卫生问题。紫外线辐射(UVR)，特别是室内日光浴产生的紫外线辐射，对皮肤癌的风险很大。室内晒黑正变得越来越普遍，在青少年和年轻成年女性中尤其受欢迎。虽然许多室内晒黑是因为外表原因，但经常晒黑的一部分人可能会在心理和身体上对晒黑产生依赖。有证据表明，紫外线照射会在体内产生物质(如阿片类β-内啡肽)，可能会增加积极的感觉和晒黑的欲望。该项目的主要目的是测试一种新的实验范式的可行性和可接受性，以调查UVR暴露的情感(情感)和生物决定因素以及对UVR暴露的反应，这些因素可能会激励正在进行的室内晒黑行为。18-25岁的经常和不经常在室内晒黑的女性将被招募并随机分配到标准商业日光浴摊位接受紫外线照射和非紫外线照射(安慰剂)，采用受试者内交叉设计。参与者将在紫外线照射前后完成心理访谈、问卷调查和血液样本。据推测，频繁和不频繁的室内晒黑在心理/情感和生物标记物(ACTH、β-内啡肽)基线水平和对UVR暴露的反应以及遗传多态(Mu-阿片受体，OPMR1)方面将存在显著差异。我们的团队已经成功地在年轻人中进行了几项皮肤癌预防和成瘾研究；因此，我们非常适合和独特地准备进行拟议的项目。这种创新和翻译性的工作对于理解晒黑欲望背后的心理和生物过程非常重要，特别是经常在室内晒黑的人，他们暴露在最具破坏性的紫外线辐射下。更好地了解这些过程可能有助于制定更有效的预防努力，并有助于指导这一领域的公共政策。 与公共健康相关：紫外线照射，特别是来自室内日光浴等人工来源的紫外线照射，极大地促进了皮肤癌，皮肤癌是人类最常见的恶性肿瘤形式。这项拟议的研究旨在更好地了解与室内晒黑行为有关的心理和生物过程，这些人是皮肤损伤的高危人群：年轻的成年女性。更好地了解这些过程可能有助于制定更有效的预防努力，并有助于指导这一领域的公共政策。

DESCRIPTION (provided by applicant): As the most common human malignancy, skin cancer is a major public health concern. Ultraviolet radiation (UVR), specifically that produced by indoor tanning booths contributes significant risk for skin cancer. Indoor tanning is becoming increasingly prevalent and is particularly popular among adolescent and young adult females. While many indoor tanners tan for appearance reasons, a subgroup of frequent tanners may become psychologically and physically dependent on tanning. There is evidence that UVR exposure produces substances in the body (e.g., the opioid beta-endorphin) that may increase positive feelings and the desire to tan. The primary aim of the proposed project is to test the feasibility and acceptability of a novel experimental paradigm to investigate the affective (emotional) and biological determinants of and responses to UVR exposure that may motivate ongoing indoor tanning behavior. 18-25 year-old female frequent and infrequent indoor tanners will be recruited and randomly assigned to receive UVR and non-UVR (placebo) light from standard commercial tanning booths in a within-subjects cross-over design. Participants will complete a psychological interview, questionnaires, and blood samples before and after UVR exposure. It is hypothesized that there will be significant differences between the frequent and the infrequent indoor tanners in psychological/affective and biomarker (ACTH, beta-endorphin) baseline levels and responses to UVR exposure, as well as genetic polymorphisms (the mu-opioid receptor, OPMR1). Our team has successfully conducted several previous skin cancer prevention and addiction studies with young adults; thus, we are ideally suited and uniquely poised to conduct the proposed project. Such innovative and translational work is important to understanding the psychological and biological processes underlying the desire to tan, particularly among frequent indoor tanners who are exposed to the greatest levels of damaging UVR. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area. PUBLIC HEALTH RELEVANCE: Ultraviolet radiation exposure, especially when from artificial sources such as indoor tanning booths, contributes greatly to skin cancer, the most common form of human malignancy. The proposed study seeks to better understand the psychological and biological processes related to indoor tanning behavior among those at high risk for skin damage: young adult females. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area.