Health Outcomes in Blood Donors and Recipients

描述(由申请人提供)：墨菲博士是一位久负盛名、资金雄厚、富有成效的研究人员，他在第一个资助周期中有效地利用了K24机制，以利用他对患者导向研究(POR)的参与，并投入大量额外时间进行培训和指导。他在研究生、研究员和初级教员的传统指导方面取得了成功，帮助他们在POR中实现了自己的职业生涯。更具新颖性，但仍完全在K24奖项的意图范围内，他在发展中国家为输血医学博士和博士设立了一个充满活力的新POR培训计划，将导致新一代研究人员致力于在全球范围内提高输血的安全性和可用性。最后，在研究和培训活动与对行政职责的剩余承诺之间，仍然存在对时间和资金工资的竞争要求。尽管中长期导师制取得了成功，但国际项目仍然很年轻，申请者希望有更多的时间让几名有前途的学员从短期课程过渡到中长期导师制。需要额外五年的资金，以建立国际输血安全POR培训英才中心：继续并扩大他的高质量POR计划，重点研究输血传播病毒的健康结果和遗传流行病学。在加州大学伯克利分校CTSI、加州大学伯克利分校公共卫生学院和加州大学伯克利分校新的路线图K12硕士和博士项目的保护伞下，继续并增加中长期指导。与加州大学旧金山分校全球卫生研究所和NIH Fogarty国际中心培训赠款合作，扩大并获得国际培训活动的独立资金，进一步加强他自己的研究团队，促进初级教员的独立性，并联合(UCSF和BSRI)招聘一名遗传流行病学家，以帮助实验室扩展到这一新的研究领域。相关性(见说明)：这项研究培训补助金将支持申请者努力进行以患者为中心的研究，并培训年轻的内科科学家进行此类研究。该提案将培训美国的研究生、博士后研究员和初级教员，以及发展中国家的输血医生。

DESCRIPTION (provided by applicant): Dr. Murphy is a well-established, well-funded and productive researcher who has productively utilized the K24 mechanism during the first funding penod to leverage his participation in patient onented research (POR) and to devote substantial additional time to training and mentoring. He has been successful in traditional mentoring of graduate students, fellows and junior faculty towards their own career in POR. More novel, but still fully within the scope of the K24 award's intent, he has instituted a dynamic new program in POR training for transfusion medicine MD's and PhD's in developing countries that will lead to a new generation of researchers devoted to improving the safety and availability of blood transfusion on a woridwide basis. Finally, there are still competing demands for time and funded salary between research and training activities and remaining commitments to administrative duties. Although medium-long term mentorship has been successful, the international program is still young and the applicant would like more time for several promising trainees from the short course to transition to medium to long term mentorship. An additional five years of funding is requested to enable the formation of a Center of Excellence in POR training in international transfusion safety: Continue and expand his program of high quality POR, with a research concentration on the health outcomes of transfusion transmitted viruses and genetic epidemiology. Continue and increase medium- and long-term mentorship under the umbrella of the UCSF CTSI, UC Berkeley School of Public Health and the new roadmap K12 Masters and Ph.D. programs at UCSF. Expand and obtain independent funding for international training activities, in collaboration with the UCSF Institute for Global Health, and NIH Fogarty International Center training grants Further strengthen his own research team, promoting the independence of junior faculty and a joint (UCSF and BSRI) recruitment of a genetic epidemiologist to aid the laboratory's expansion into this new area of research. RELEVANCE (See instructions): This research training grant will support the applicant in his efforts to perform patient oriented research, and to train younger physician scientists to do this kind of research. The proposal will train graduate students, postdoctoral fellows and junior faculty in the USA and transfusion doctors in developing countries.