CORE A: ADMINISTRATIVE CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项Cobre提案的主要目标是增加NIH支持的南卡罗来纳州的生物医学研究人员的数量，特别是在克莱姆森大学(CU)。为此，CU在生物材料和组织工程方面的独特优势将得到南卡罗来纳医科大学(MUSC)和南卡罗来纳大学(USC)在医学和发育生物学方面的专业知识的补充，以在CU建立组织再生生物材料中心(CBTR)。为了实现该中心的目标，一批优秀的导师指导初级调查人员走向独立，成为NIH支持的调查人员。该中心的组织再生主题同时符合南卡罗来纳州在再生医学方面的优势，同时解决了全球范围内死亡和发病的一个重要原因：终末期器官衰竭和组织丢失每年仅在美国就造成近4000亿美元的医疗成本。组织再生的研究提供了通过修复功能组织来减轻这些人力和经济成本的可能性。该中心的科学重点是通过细胞生物材料相互作用来调节组织再生。来自初级调查人员的五个项目已经被严格挑选出来，以适应这一主题。这些项目是1)通过激光图案化细胞桥的干细胞-肌肉细胞电耦合；2)用于引导神经再生的生物材料；3)了解和控制组织特有的血管图案化；4)机械引导的体外泌尿组织再生；以及5)中风后脑组织再生的使能技术。两个试点项目也得到了成本分摊资金的支持。这些目标研究人员与导师配对，这些导师是由NIH支持的、在指导方面有出色记录的研究人员，以及将保持项目临床相关性的外科医生。这些项目得到了组织良好的基础设施和三个最先进的核心设施(材料合成、表征和测试、组织学和成像以及细胞和分子工程)的支持。我们国家认可的外部咨询委员会成员将对该中心的进展进行批判性的评估。这个科布雷中心将大大加强南卡罗来纳州的合作努力，以招募、培训和留住一大批具有跨学科技能的研究人员，以便在再生医学研究领域进行有效合作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary goal of this COBRE proposal is to increase the number of NIH-supported biomedical researchers in the state of South Carolina, particularly at Clemson University (CU). For this purpose, CU's unique strengths in biomaterials and tissue engineering will be complemented by expertise in medicine and developmental biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) to establish a Center of Biomaterials for Tissue Regeneration (CBTR) at CU. To accomplish the center's goal, an outstanding cadre of mentors mentor junior investigators toward independence as NIH-supported investigators. The center's tissue-regeneration theme simultaneously fits South Carolina's strength in regenerative medicine while addressing a significant cause of mortality and morbidity worldwide: End-stage organ failure and tissue loss create healthcare costs of nearly $400 billion annually in the US alone. Research in tissue regeneration offers the possibility of relief for these human and economic costs through restoration of functional tissues. The scientific focus of this center is regulation of tissue regeneration through cell biomaterials interactions. Five projects from junior investigators have been rigorously selected to fit this theme. These projects are 1) Stem cell-myocyte electrical coupling via a laser-patterned cell bridge; 2) Biomaterials for guided neural regeneration; 3) Understanding and Controlling Tissue-specific Vascular Patterning; 4) Mechanically guided urological tissue regeneration in vitro; and 5) Enabling Technology for Brain Tissue Regeneration after Stroke. Two pilot projects are also supported from cost share money. These target investigators are paired with mentors who are established, NIH-supported researchers with excellent track records in mentoring and with surgeons who will keep projects clinically relevant. The projects are supported by a well-organized infrastructure and three state-of-the-art core facilities (Materials Synthesis, Characterization and Testing, Histology and Imaging, and Cell and Molecular Engineering). Our nationally recognized External Advisory Committee members will critically evaluate the center's progress. This COBRE center will significantly augment collaborative efforts in South Carolina to recruit, train, and retain a critical mass of investigators with cross-disciplinary skills to collaborate effectively in the research area of regenerative medicine.