CORE A1: MENTORING CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项COBRE提案的主要目标是增加南卡罗来纳州，特别是克莱姆森大学（CU）的NIH支持的生物医学研究人员的数量。为此，CU在生物材料和组织工程方面的独特优势将得到南卡罗来纳州医科大学（MUSC）和南卡罗来纳州大学（USC）医学和发育生物学专业知识的补充，以在CU建立组织再生生物材料中心（CBTR）。为了实现该中心的目标，一个优秀的导师骨干指导初级研究人员走向独立的NIH支持的研究人员。该中心的组织再生主题同时符合南卡罗来纳州在再生医学方面的优势，同时解决全球死亡率和发病率的重要原因：仅在美国，终末期器官衰竭和组织损失每年就造成近4000亿美元的医疗费用。组织再生的研究提供了通过恢复功能组织来减轻这些人力和经济成本的可能性。该中心的科学重点是通过细胞生物材料相互作用调节组织再生。从初级调查员中严格挑选了五个项目来适应这一主题。这些项目是1）通过激光图案化细胞桥的干细胞-肌细胞电耦合; 2）用于引导神经再生的生物材料; 3）理解和控制组织特异性血管图案; 4）体外机械引导泌尿组织再生;和5）中风后脑组织再生的技术。两个试点项目也得到了费用分摊资金的支助。这些目标研究者与导师配对，导师是建立的，NIH支持的研究人员在指导方面有着出色的记录，外科医生将保持项目的临床相关性。这些项目得到了组织良好的基础设施和三个最先进的核心设施（材料合成，表征和测试，组织学和成像以及细胞和分子工程）的支持。我们国家认可的外部咨询委员会成员将严格评估中心的进展。该COBRE中心将显著增强南卡罗来纳州的合作努力，以招募、培训和保留具有跨学科技能的关键数量的研究人员，从而在再生医学研究领域进行有效合作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary goal of this COBRE proposal is to increase the number of NIH-supported biomedical researchers in the state of South Carolina, particularly at Clemson University (CU). For this purpose, CU's unique strengths in biomaterials and tissue engineering will be complemented by expertise in medicine and developmental biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) to establish a Center of Biomaterials for Tissue Regeneration (CBTR) at CU. To accomplish the center's goal, an outstanding cadre of mentors mentor junior investigators toward independence as NIH-supported investigators. The center's tissue-regeneration theme simultaneously fits South Carolina's strength in regenerative medicine while addressing a significant cause of mortality and morbidity worldwide: End-stage organ failure and tissue loss create healthcare costs of nearly $400 billion annually in the US alone. Research in tissue regeneration offers the possibility of relief for these human and economic costs through restoration of functional tissues. The scientific focus of this center is regulation of tissue regeneration through cell biomaterials interactions. Five projects from junior investigators have been rigorously selected to fit this theme. These projects are 1) Stem cell-myocyte electrical coupling via a laser-patterned cell bridge; 2) Biomaterials for guided neural regeneration; 3) Understanding and Controlling Tissue-specific Vascular Patterning; 4) Mechanically guided urological tissue regeneration in vitro; and 5) Enabling Technology for Brain Tissue Regeneration after Stroke. Two pilot projects are also supported from cost share money. These target investigators are paired with mentors who are established, NIH-supported researchers with excellent track records in mentoring and with surgeons who will keep projects clinically relevant. The projects are supported by a well-organized infrastructure and three state-of-the-art core facilities (Materials Synthesis, Characterization and Testing, Histology and Imaging, and Cell and Molecular Engineering). Our nationally recognized External Advisory Committee members will critically evaluate the center's progress. This COBRE center will significantly augment collaborative efforts in South Carolina to recruit, train, and retain a critical mass of investigators with cross-disciplinary skills to collaborate effectively in the research area of regenerative medicine.