Claude D. Pepper Older Americans Independence Centers (OAICS) (P30)

描述（由申请人提供）：这是密歇根大学Claude D. Pepper老年美国人独立中心（UM Pepper中心）的竞争性续期申请。亚利桑那大学胡椒中心的具体目标是：1)通过更好地了解影响老年表型发展的预测因子和调节因子，包括健康老龄化和一系列残疾结果，支持重点关注增强老年人独立性的研究。2)通过支持将老龄和导致残疾的老年人常见健康问题的基础研究与临床研究联系起来的转化研究，帮助维持和恢复老年人的独立性。3)提供资源核心（rc），以支持和协助研究者发起的研究项目，这些项目可以对导致老年表型（包括共病和独立性丧失）的基本机制和潜在条件产生新的见解，并开发和测试适用于此类研究项目的创新方法。4)通过其研究职业发展核心（RCDC），加强UM培养未来学术领袖的环境，这些学术领袖将从事老年表型机制的研究，并开展转化研究，以提高老年人的独立性。5)通过其试点和探索性研究核心（PESC），吸引澳大初级教师（或先前未参与衰老研究的精选高级教师）研究易导致衰老表型的问题，并开展转化研究以减少残疾结果。亚利桑那大学胡椒研究中心目前已连续20年获得NIA资助，拥有完善的领导和行政结构，一个RCDC，一个PESC和四个rc：人类受试者和评估核心；生物力学核心；方法论、数据管理与分析核心以及老年啮齿动物中心设施。机构方面的支持非常突出，其中包括澳大承诺在拟议的五年更新期内提供近200万澳元的直接费用。RCDC有三个核心要素：1)一个有竞争力的项目，选择有前途的澳大青年教师进行与澳大胡椒中心研究重点相关的研究，并获得工资支持；2)为从事此类研究的初级教师提供全国认可的研究培训计划；3)为初级教师提供与一名或多名澳大高级研究员密切合作的机会的导师计划。PESC通过严格的外部审查，每年将资助5个或更多的试点项目。RCs将支持23个外部资助的项目，辣椒中心试点拨款和RCDC初级教师，并继续开发和测试胡椒中心研究中使用的新方法。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators influencing the development of aged phenotypes, including healthy aging and a range of disablement outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic with clinical research on aging and common health problems of older adults leading to disability. 3) To provide Resource Cores (RCs) to support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to aged phenotypes including comorbidity and loss of independence and which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders who will conduct research on mechanisms contributing to aged phenotypes, and initiate translational research to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty (or selected senior faculty not previously involved in aging research) to study problems predisposing to aged phenotypes and to carry out translational research to reduce disablement outcomes. The UM Pepper Center, now in its 20"^ year of continuous NIA funding, has in place a well established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core; the Biomechanics Core; the Methodology, Data Management and Analysis Core; and the Core Facility for Aged Rodents. There is outstanding institutional support, including a UM commitment of almost $2 million of direct costs over the proposed 5 years of this renewal. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 5 or more pilot projects per year. The RCs will support 23 externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.