Mentoring a Cancer Genetics Program

描述(由申请人提供)：本次Cobre续签申请的目标是继续发展癌症遗传学领域有前途的初级研究人员的研究生涯，并在该领域建立核心计划力量。职业发展将利用强大的研究导师核心，他们将提供职业发展建议以及关于科学发展和实验室管理的合理实用建议。这个科布雷的五个项目集中了几个重叠的主题中的一个，这些主题有助于我们理解遗传不稳定、细胞炎症和细胞对这些因素的反应。除了一项之外，所有的提案都专门关注用于研究癌症的小鼠模型，而且所有的项目都具有很高的翻译相关性。由导师和核心董事组成的内部咨询委员会都坚定地致力于该计划，并拥有出色的研究和指导记录。此外，一个具有杰出研究生涯和初级科学家职业发展记录的知名外部顾问委员会将参与初级调查人员和科布雷方案本身进展的指导和评估。职业发展将包括一系列项目会议、授课拨款撰写会议和研讨会，以为初级教员以及路易斯安那州癌症研究联盟(LCRC)的其他成员发展一个高度协作的环境。科布雷还为我们的科学家提供出色的核心设施开发，使他们可以进行新的实验。LCRC为杜兰大学、路易斯安那州立大学健康科学中心和泽维尔大学的癌症研究提供了一个出色的跨学科和跨机构的环境。LCRC的资金来自长期的州烟草税，明确的目标是竞争NCI作为新奥尔良癌症中心的称号。土发公司在未来数年提供出色的招聘服务、一座专供土发公司使用的新大楼，以及一系列运作良好的核心设施。该中心代表了最不发达国家权利委员会的核心，为我们在卡特里娜飓风过后的重建做出了巨大贡献，并提供了帮助指导整个最不发达国家权利委员会指导和发展的框架。 公共卫生相关性(由申请者提供)：我们的许多年轻教员成功地获得了他们的第一笔NIH R0I资金，我们相信我们将在续签中实现更大的增长。这将极大地增强路易斯安那州东南部的研究资金基础和辅导池。此外，这里描述的科学计划和核心提供了旨在抗击癌症的杰出的和高度转化的项目。

DESCRIPTION (provided by applicant): The objective of this COBRE renewal application is to continue to develop the research careers of promising junior investigators In Cancer Genetics and to build core Programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and lab management. The five projects in this COBRE focus one several overlapping themes that contribute to our understanding of genetic instability, cellular inflammation, and the cell's responses to these factors. All but one of the proposals specifically focus on mouse models for studying cancer, and all projects have a high translational relevance. An internal advisory committee composed of mentors and core directors for this COBRE are all strongly committed to the program, and have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Louisiana Cancer Research Consortium (LCRC). The COBRE also provides outstanding core facility development for our scientists to make new experiments available to them. The LCRC provides an outstanding interdisciplinary and inter-institutional environment for cancer research involving Tulane University, LSU Health Sciences Center and Xavier University. The LCRC is funded by a long-term state tobacco tax with the express goal of competing for NCI designation as a cancer center in New Orleans. The LCRC provides outstanding recruitment in the next few years, a new building dedicated to the LCRC and a series of well-operated core facilities. This COBRE represents the centerpiece of the LCRC and contributed strongly to our rebuilding post-Katrina as well as providing the framework that helps guide mentoring and development throughout the LCRC. PUBLIC HEALTH RELEVANCE (provided by applicant): This COBRE has been responsible for the success of a number of our young faculty obtaining their first NIH R0I funding and we believe we are poised for even more growth in the renewal. This will greatly enhance the research funding base and mentoring pool in Southeastern Louisiana. In addition, the scientific programs and cores described here provide outstanding and highly translational projects aimed at combating cancer.