ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS ANIMAL MODEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（由申请方提供）：寄生性人类病毒及其猿猴对应物在遗传组成上相似，并在其免疫抑制宿主中诱导相似的疾病谱。 实验性慢病毒感染恒河猴被广泛认为是艾滋病相关研究的最重要的动物模型，迫切需要扩大育种计划，以满足未来艾滋病疫苗和发病机制研究计划的需求。 印度恒河猴繁殖殖民地的机会性病毒制剂的发展，提出了提高这种独特的资源的有用性，研究重点是艾滋病相关的机会性感染。 住房空间的建议，以提供一个受保护的环境，这种独特的扩大特定病原体免费（ESPF）猕猴资源，并促进增强猕猴繁殖的努力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Opportunistic human viruses and their simian counterparts are similar in their genetic makeup and induce a similar spectrum of diseases in their immunosuppressed hosts. Experimental lentivirus infections in rhesus macaques are wildly recognized as the most import animal model for AIDS-related research and there is an urgent need to expand breeding programs to meet future AIDS vaccine and pathogenesis research program needs. Development of an Indian rhesus macaque breeding colony free of opportunistic viral agents is proposed to enhance the usefulness of this unique resource for studies focused on AIDS-related opportunistic infections. Housing space is proposed to provide a protected environment for this unique Expanded Specific Pathogen Free (ESPF) macaque resource and to facilitate enhanced macaque breeding efforts.