Claude D. Pepper Older Americans Independence Centers (OAICS) (P30)

描述（由申请人提供）：这是Claude D的竞争性续期申请。密歇根大学胡椒老年美国人独立中心（UM胡椒中心）。UM Pepper中心的具体目标是：1）通过更好地了解影响老年表型发展的预测因子和调节因子（包括健康老龄化和一系列残疾结果），支持重点增强老年人独立性的研究。2)通过支持将基础研究与临床研究联系起来的转化研究，帮助维持和恢复老年人的独立性，研究老龄化和导致残疾的老年人常见健康问题。3)提供资源核心（RC），以支持和协助研究者发起的研究项目，这些项目可以导致对导致老年表型（包括合并症和丧失独立性）的基本机制的新见解，并开发和测试适用于此类研究项目的创新方法。4)通过其研究职业发展核心（RCDC），加强UM环境，培养未来的学术领袖，他们将对老年表型的机制进行研究，并启动转化研究，以提高老年人的独立性。5)通过其试点和探索性研究核心（PESC），吸引UM初级教师（或以前未参与老龄化研究的选定高级教师）研究易患老年表型的问题，并进行转化研究，以减少残疾结果。UM Pepper中心目前已连续20年获得NIA资助，已建立了完善的领导和行政结构，一个RCDC，一个PESC和四个RC：人类受试者和评估核心;生物力学核心;方法，数据管理和分析核心;以及老年啮齿动物核心设施。有杰出的机构支持，包括UM承诺在拟议的5年延长期内支付近200万美元的直接费用。RCDC具有三个核心要素：1）一个有竞争力的计划，以选择有前途的UM初级教师的工资支持进行相关的研究UM胡椒中心的研究重点; 2）一个国家认可的研究培训计划，为初级教师从事这样的研究，和3）一个导师计划，提高初级教师的机会，与一个或多个UM高级研究人员密切合作。通过严格的外部审查，PESC每年将资助5个或更多的试点项目。RC将支持23个外部资助的项目，胡椒中心试点赠款和RCDC初级教师，并继续开发和测试新方法用于胡椒中心的研究。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators influencing the development of aged phenotypes, including healthy aging and a range of disablement outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic with clinical research on aging and common health problems of older adults leading to disability. 3) To provide Resource Cores (RCs) to support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to aged phenotypes including comorbidity and loss of independence and which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders who will conduct research on mechanisms contributing to aged phenotypes, and initiate translational research to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty (or selected senior faculty not previously involved in aging research) to study problems predisposing to aged phenotypes and to carry out translational research to reduce disablement outcomes. The UM Pepper Center, now in its 20"^ year of continuous NIA funding, has in place a well established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core; the Biomechanics Core; the Methodology, Data Management and Analysis Core; and the Core Facility for Aged Rodents. There is outstanding institutional support, including a UM commitment of almost $2 million of direct costs over the proposed 5 years of this renewal. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 5 or more pilot projects per year. The RCs will support 23 externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.