COBRE: NDSU: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASE IN DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 2001年，在科布雷计划的资助下，成立了蛋白酶研究中心。之前的拨款申请主要集中在化学方面，而这次继续申请将有很强的生物学成分，癌症和哮喘是主要的疾病目标。了解基质金属蛋白酶和组蛋白脱乙酰酶在癌症和哮喘等其他疾病中所起的生物学作用将是一个主要的科学目标。 该中心将协调4名新调查人员的专业知识：化学和分子生物学系的Glenn Dorsam和Gregory Cook；制药科学系的郭斌；以及兽医和微生物科学系的Jane Scheh。生物和合成化学方面的核心设施将在协助新的PI、南大其他研究人员和北达科他州INBRE研究人员的研究计划方面发挥关键作用。该中心将继续建设基础设施，启动新的活动，并继续实施以前成功的计划，以促进北达科他州生物医学研究的增长。 抗击癌症是人类死亡的主要原因之一，也是生物医学科学家的主要目标。南加州大学科布雷中心将进行研究，以提供有关蛋白酶如何影响癌症的基本信息。蛋白酶是几种疾病的关键生物学参与者。这些研究有可能提供治疗这种致命疾病的新疗法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center for Protease Research was established in 2001 with funds from the COBRE program. The previous grant application had a strong focus on chemistry, while this continuation will have a strong biology component with cancer and asthma as the primary disease targets. Understanding the biological role played by matrix metalloproteinases and histone deacetylases in cancer and other diseases such as asthma will be a major scientific goal. The Center will coordinate the expertise of 4 new investigators: Glenn Dorsam and Gregory Cook, Department of Chemistry and Molecular Biology; Bin Guo, Department of Pharmaceutical Sciences; and Jane Schuh, Department of Veterinary and Microbiological Sciences. Core Facilities in biology and synthetic chemistry will play a key role in assisting the research programs of the new PI's, other NDSU researchers, and North Dakota INBRE researchers. The Center will continue to build infrastructure, initiate new activities, and continue previously successful programs to foster growth of biomedical research in North Dakota. Combating cancer, one of the leading causes of mortality in humans, is a major goal for biomedical scientists. The NDSU COBRE center will conduct research to provide fundamental information on how proteases, a key biological player in several diseases, impacts cancer. These studies have the potential to provide novel therapeutics that can treat this deadly disease.