SPF COLONY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的中心目标是培育无特定病原体(SPF)的猕猴，并从遗传特征上鉴定MHC和全系。这些动物可作为NIH支持的艾滋病相关研究的研究人员的研究对象，并为国家卫生优先事项做出贡献。 这一目标是在该中心通过利用现有的SPF猕猴群体实现的。通过繁殖和招募来自非SPF繁殖群体的幼年动物进行分离和病毒筛选，扩大了这个群体。通过定期采集血样进行检测，对菌落进行病毒维持。该项目提供必要的训练有素的人员和资源，以维持和扩大SPF繁育群体并对其进行管理，以优化健康和生殖性能，支持与国家健康有关的优先事项。 YNPRC与NCRR和协调委员会密切合作，执行关于统一饲养程序、筛选测试标准化和委员会认为必要的其他事项的建议。为了最大限度地满足国家在SOF生产方面的优先事项，YNPRC与其他设施和NCRR确定的调查人员合作，维护NCRR支持的SOF殖民地。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The central objective of this project is to breed macaques that are specific pathogen free (SPF and genetically characterized for MHC and full pedigree. These animals are made available as subjects to NIH supported investigators for AIDS related research and contribute to national health priorities. This objective is achieved at the center by utilizing an existing colony of SPF macaques. This colony is expanded via breeding and recruitment of young animals from non-SPF breeding colonies for separation and viral screening. The colonies are virally maintained by routine blood collection for testing at specified intervals. This project provides trained personnel and resources that are necessary to maintain and expand the SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities. The YNPRC works closely with NCRR and the Coordinating Committee to implement recommendations regarding uniform husbandry procedures, standardization of screening tests and such other matters as the committee may deem necessary. To maximize the potential that national priorities for SOF production will be met, the YNPRC works in conjunction with other facilities, and investigators identified by NCRR, to maintain NCRR supported SOF colonies.