SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：该COBRE计划旨在汇集南卡罗来纳州医科大学现有的氧化剂，氧化还原平衡和压力信号方面的专业知识的个人。我们的长期计划是在南卡罗来纳州发展一个卓越的中心，在这个科学学科或与这个科学的重点。为此，我们已经构建了一个基础设施，将提供一个指导的环境，为五个目标教师与钙蛋白酶和糖尿病信号通路，线粒体中的氧化途径，活性氧（ROS）和氮（RNS）物种和过氧化物酶在癌症的启动，ROS/RNS和未折叠的蛋白质反应和神经元细胞死亡的氧化途径的研究兴趣。他们的项目提供了跨学科的机会，并得到蛋白质组学，代谢组学和细胞与分子成像三个科学核心的支持。核心假设是氧化还原调节途径对疾病如癌症、衰老、糖尿病、炎症和神经变性的病理生物学有显著影响。行政核心将促进过多的功能，包括业务管理，教师发展，指导和计划规划和可持续性。我们任命了监督委员会，包括指导委员会、内部顾问委员会和外部顾问委员会。后两个小组包括在所选学科中具有广泛科学知识和丰富指导经验的个人。该计划的未来发展也得到了MUSC的财政支持，并创造了新的和翻新的空间，这将允许额外的教师招聘与互补的专业知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise.