Biomechanics and Multimodal Tissue Imaging Core

生物力学和多模态组织成像（BMTI）核心是由于肌肉骨骼研究中心（CMSR）的资源战略重组而提出的，以提高效率，加快研究步伐，并促进我们NIH资助项目的临床翻译。随着CMSR的研究朝着越来越多的转化方向发展，包括许多动物模型 骨科损伤和修复（如关节炎、骨折愈合和同种异体移植物愈合）的最新进展，将组织学、组织和细胞研究与纵向动物成像和组织生物力学评估相结合，以追求可以从实验室转移到床边的微创愈合和修复结果测量，已经有了令人信服的理由。CMSR的自然增长和成功， 为了加强CMSR和韦尔斯通肌营养不良症合作研究中心（MDCRC）之间的合作，最近对我们的骨骼组织病理学设施进行了改造，以及通过最近的ARRA奖励获得了最先进的尖端技术，现在有必要对我们的资源进行组织结构调整，将组织学、生物化学 和分子成像（HBMI）核心和生物力学和多模态组织成像（BMTI）核心。此次重组旨在确保继续为CMSR的研究者提供高效、高质量的组织形态学、组织学、生物力学和体内成像服务，从而使各个实验室不必不断重复技术进步和修改。此外，BMTI核心旨在为我们的肌肉骨骼生物学和医学核心中心（CCMBM）的无资金医生科学家（UPS）和研究助理教授（RAP）提供更多的服务核心的大型仪器费用。BMTI核心的目的是在肌肉骨骼的小动物模型中提供高质量、一致、高效和具有成本效益的解剖成像和生物力学测试。 创伤和疾病;增强和完善成像模式和新的图像处理算法，以获得功能愈合的翻译相关性;并为RAP和UPS提供负担得起的核心资源，并利用其独特的研究专长来培训CCMBM的其他研究人员，工作人员和学员。我们选择的方法旨在以最高的效率和质量水平改善对我们资助的研究人员的服务，并促进我们的RAP和UPS的独立性，使他们成为未来的领导者，有可能被该国的顶级学术课程所招募。

The Biomechanics and Multimodal Tissue Imaging (BMTI) Core is being proposed as a result of strategic restructuring of resources in the Center for Musculoskeletal Research (CMSR), in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation of our NIH funded programs. As the research in the CMSR has moved in increasingly translational directions, including many animal models of orthopaedic injury and repair (e.g. arthritis, fracture healing, and allograft healing), there has been a compelling rationale for integrating histologic, tissue- and cell-based studies with longitudinal animal imaging and tissue biomechanical assessments, in pursuit of minimally-invasive outcome measures of healing and repair that can be translated from the bench to the bedside. The natural growth and success of the CMSR, the new initiative to increase collaborations between the CMSR and the Wellstone Muscular Dystrophy Cooperative Research Centers (MDCRC), the recent revamping up of our skeletal histopathology facilities, and the acquisition of state-of-the-art, sophisticated technologies through recent ARRA awards now necessitate the proposed organizational restructuring of our resources into separate Histology, Biochemistry and Molecular Imaging (HBMI) Core and Biomechanics and Mulfimodal Tissue Imaging (BMTI) Cores. This restructuring is sought to ensure the continued provision of efficient, high quality, histomorphometric, histologic, biomechanics, and in vivo imaging services to the investigators in the CMSR, such that the individual labs do not have to continually reproduce technical advances and modifications. Furthermore, the BMTI Core is designed to provide greater access of our large instrument fee for service Cores to unfunded physician scientists (UPS) and Research Assistant Professors (RAP) in our Core Center for Musculoskeletal Biology and Medicine (CCMBM). The Aims of the BMTI Core are to provide high quality, consistent, efficient and cost-effective anatomic imaging and biomechanical testing in small animal models of musculoskeletal trauma and disease; to enhance and refine imaging modalities and novel image processing algorithms to derive translational correlates of functional healing; and to provide affordable access for RAP and UPS to Core resources, and utilize their unique research expertise to train other investigators, staff, and trainees in the CCMBM. The approach we have chosen is designed to improve service to our funded investigators at the highest levels of efficiency and quality, and facilitate the advancement of our RAP and UPS to independence, establishing them as future leaders that could potentially be recruited by the top academic programs in the country.