STRUCTURE OF A BACTERIAL HOMOLOG OF VITAMIN K EPOXIDE REDUCTASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 维生素K环氧化物还原酶(VKOR)产生维生素K对苯二酚，维持多种凝血因子的伽玛羧化。该酶也是最常用的口服抗凝剂华法林的靶标。在包括细菌在内的许多生物体中都发现了VKOR的同源物。在细菌中，VKOR参与二硫键的形成。该项目的目标是确定VKOR的细菌同源物的结构。这将使我们深入了解电子转移的机制，并阐明华法林抑制的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain gamma-carboxylation of many blood coagulation factors. The enzyme is also the target of warfarin, the most commonly used oral anticoagulant. Homologs of VKOR have been discovered in many organisms, including bacteria. In bacteria, VKOR is involved in disulfide bridge formation. The goal of the project is to determine the structure of a bacterial homolog of VKOR. This would allow insight into the mechanism of electron transfer and shed light on the mechanism of warfarin inhibition.