Translational Cancer Biology Training Program

描述（由申请人提供）：本申请旨在资助马萨诸塞州医学院（UMMS）的癌症生物学新培训计划，该计划将支持六名博士后和两名博士前学员，他们致力于癌症研究的职业生涯。该计划将设在UMMS的癌症生物学系，但它将包括来自多个基础科学和临床部门的教师。根据他们的科学成就和癌症研究资金的跟踪记录，对转化癌症研究的赞赏以及他们在指导学员方面的经验，教师被选中参加该计划。这个跨部门计划的主要目的是为学员提供，其中大多数将是基础科学家，对转化癌症研究的赞赏，并与影响和指导他们职业生涯的临床医生有效互动的能力。三个关键的发展证实了UMMS对癌症的承诺，并证明了我们对培训计划的要求。该医学院于2002年成立了癌症生物学系，并聘请耶鲁大学的Dario Altieri博士担任其创始主席。第二，Altieri博士还被任命为麻省大学癌症中心主任，负责扩大和加强该中心的影响。最后，在生物医学科学研究生院的主持下，形成了一个新的癌症生物学研究生课程。正如下面将更详细讨论的那样，所有这三项努力都是紧密结合的。癌症生物学系是癌症中心的基石，研究生课程与癌症中心的课程有关。这些努力的首要主题是转化癌症研究。更具体地说，他们的中心使命是利用UMMS存在的非凡的基础科学企业对人类癌症的临床管理，反过来，使临床问题能够影响和指导基础科学。从本质上讲，这些是翻译研究的定义原则。这一方法及其实施所产生的基础设施为研究生和博士后研究员的培训提供了一个出色的环境。事实上，拟议的培训计划是我们的癌症使命的一个关键组成部分，它是基于我们的哲学转化和跨部门的癌症研究。

DESCRIPTION (provided by applicant): This application seeks funding of a new training program in Cancer Biology at the University of Massachusetts Medical School (UMMS) that will support six post-doctoral and two pre-doctoral trainees who are committed to careers in cancer research. The program will be based in the Department of Cancer Biology at UMMS but it will include faculty from multiple basic science and clinical departments. Faculty have been selected for participation in this program based on their scientific achievements and track record of funding in cancer research, appreciation for translational cancer research and their experience in mentoring trainees. A major intent of this inter-departmental program is to provide the trainees, most of whom will be basic scientists, with an appreciation for translational cancer research and with the ability to interact effectively with clinicians that will influence and guide their careers. Three key developments substantiate the commitment of UMMS to cancer and justify our request for a training program. The medical school established a Department of Cancer Biology in 2002 and recruited Dr. Dario Altieri from Yale to be its founding Chair. Second, Dr. Altieri was also named Director of the UMass Cancer Center and charged with expanding and enhancing the impact of this center. Lastly, a new graduate program in cancer biology was formed that is inter-departmental under the auspices of the Graduate School of Biomedical Sciences. As will be discussed in more detail below, all three of these endeavors are closely integrated. The Department of Cancer Biology is a cornerstone of the Cancer Center, and the graduate program is linked to the programs of the Cancer Center. The overarching theme of these endeavors is translational cancer research. More specifically, their central mission is to harness the extraordinary basic science enterprise that exists at UMMS to the clinical management of human cancers and, conversely, to enable clinical problems to influence and guide basic science. In essence, these are the defining principles of translational research. This approach and the infrastructure that has resulted from its implementation provide an outstanding environment for the training of graduate students and post-doctoral fellows. Indeed, the proposed training program is a critical component of our cancer mission and it is predicated on our philosophy of translational and inter-departmental cancer research.